ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls
| Autor: | Noah B. Bonnheim, Ann A. Lazar, Anika Kumar, Zehra Akkaya, Jiamin Zhou, Xiaojie Guo, Conor O’Neill, Thomas M. Link, Jeffrey C. Lotz, Roland Krug, Aaron J. Fields |
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| Rok vydání: | 2023 |
| Předmět: |
Adult
Male Aging Clinical Trials and Supportive Activities Clinical Sciences Biomedical Engineering Bioengineering Intervertebral Disc Degeneration Disc degeneration Clinical Research T1 rho (T1rho) magnetic resonance imaging Humans Orthopedics and Sports Medicine Intervertebral Disc Lumbar Vertebrae Pain Research Neurosciences T1ρ (T1rho) magnetic resonance imaging Middle Aged Magnetic Resonance Imaging Lumbar spine Orthopedics Musculoskeletal Neurological Chronic low back pain Surgery Female Chronic Pain Low Back Pain |
| Zdroj: | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, vol 32, iss 5 |
| Popis: | Purpose Clinical management of disc degeneration in patients with chronic low back pain (cLBP) is hampered by the challenge of distinguishing pathologic changes relating to pain from physiologic changes related to aging. The goal of this study was to use imaging biomarkers of disc biochemical composition to distinguish degenerative changes associated with cLBP from normal aging. Methods T1ρ MRI data were acquired from 133 prospectively enrolled subjects for this observational study (80 cLBP, 53 controls; mean ± SD age = 43.9 ± 13.4 years; 61 females, 72 males). The mean T1ρ relaxation time in the nucleus pulposus (NP-T1ρ; n = 650 discs) was used as a quantitative biomarker of disc biochemical composition. Linear regression was used to assess associations between NP-T1ρ and age, sex, spinal level, and study group, and their interactions. Results NP-T1ρ values were lower in cLBP patients than controls (70.8 ± 22.8 vs. 76.4 ± 22.2 ms, p = 0.009). Group differences were largest at L5–S1 (ΔT1ρcLBP-control = −11.3 ms, p Conclusion Aging effects on the biochemical composition of the L5–S1 disc may involve a relatively uniform set of factors from which many cLBP patients deviate. NP-T1ρ values at L5–S1 may be highly relevant to clinical phenotyping, particularly in younger individuals. |
| Databáze: | OpenAIRE |
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