Confirming Urinary Excretion of Mephentermine and Phentermine Following the Ingestion of Oxethazaine by Gas Chromatography-Mass Spectrometry Analysis
| Autor: | Ray H. Liu, Ying Lung Tseng, Wei-Hsun Huang, Chin-Hung Liu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Phentermine medicine.drug_class Fluoroacetates Health Toxicology and Mutagenesis Acetic Anhydrides Mephentermine Urine Toxicology Gas Chromatography-Mass Spectrometry Analytical Chemistry Excretion Pharmacokinetics Oral administration medicine Humans Trifluoroacetic Acid Environmental Chemistry Ingestion Anesthetics Local Doping in Sports Chemical Health and Safety Chromatography Chemistry Local anesthetic Reproducibility of Results humanities Substance Abuse Detection Ethanolamines Anesthesia Calibration Female medicine.drug |
| Zdroj: | Journal of Analytical Toxicology. 34:73-77 |
| ISSN: | 1945-2403 0146-4760 |
| DOI: | 10.1093/jat/34.2.73 |
| Popis: | Mephentermine and phentermine, substances prohibited in sports by the World Anti-Doping Agency, were found for the first time in urine specimens following the administration of a therapeutic medication, oxethazaine. In a recent sporting event, a urine specimen donor who tested positive for mephentermine and phentermine claimed consumption of Mucaine((R)) for treating stomach pain was the reason for testing positive. Five volunteers were administrated oxethazaine (a topical anesthetic found in the multi-ingredient medication Mucaine and its generic equivalent, Stoin, both of which are available in Taiwan), mephentermine, and phentermine. Excretion profiles of mephentermine and phentermine following the administration of these drugs were found to be similar. However, the mephentermine/phentermine ratios found in urine specimens collected at different time points following the administration of oxethazine and mephentermine were found to be characteristically different. |
| Databáze: | OpenAIRE |
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