Consequences of bisphenol a perinatal exposure on immune responses and gut barrier function in mice

Autor: Eric Houdeau, Corinne Lencina, Caroline Sommer, Yann Malaisé, Sandrine Ménard, Christel Cartier, Eric Gaultier, Laurence Guzylack-Piriou
Přispěvatelé: ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Neuro-Gastroentérologie & Nutrition (ToxAlim-NGN), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Endocrinologie & Toxicologie de la Barrière Intestinale (ToxAlim-ENTeRisk), Plateforme Ezop (Ezop)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Bisphenol
Health
Toxicology and Mutagenesis
T-Lymphocytes
toxicologie alimentaire
010501 environmental sciences
Endocrine Disruptors
Toxicology
01 natural sciences
Feces
Pregnancy
période perinatale
Mice
Inbred C3H
Perinatal Exposure
Innate lymphoid cell
General Medicine
immunologic reactions
3. Good health
Isoenzymes
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Female
medicine.medical_specialty
endocrine system
Offspring
réponse immunitaire
Biology
perinatal exposure
Aldehyde Dehydrogenase 1 Family
03 medical and health sciences
Immune system
Phenols
Internal medicine
medicine
Animals
bisphénol a
Benzhydryl Compounds
intestine
0105 earth and related environmental sciences
Inflammation
Lamina propria
barrière intestinale
Retinal Dehydrogenase
Dendritic cell
Dendritic Cells
Small intestine
immune responses
Immunity
Humoral
Gastrointestinal Tract
prenatal period
030104 developmental biology
Endocrinology
Immunology
Th17 Cells
Muramidase
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Spleen
Zdroj: Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2017, on line (1), ⟨10.1007/s00204-017-2038-2⟩
Archives of Toxicology, Springer Verlag, 2017, on line, ⟨10.1007/s00204-017-2038-2⟩
ISSN: 0340-5761
1432-0738
DOI: 10.1007/s00204-017-2038-2⟩
Popis: The potent immunomodulatory effect of the endocrine disruptor bisphenol A during development and consequences during life span are of increasing concern. Particular interests have been raised from animal studies regarding the risk of developing food intolerance and infection. We aimed to identify immune disorders in mice triggered by perinatal exposure to bisphenol A. Gravid mice were orally exposed to bisphenol (50 μg/kg body weight/day) from day 15 of pregnancy until weaning. Gut barrier function, local and systemic immunity were assessed in adult female offspring. Mice perinatally exposed to bisphenol showed a decrease in ileal lysozyme expression and a fall of fecal antimicrobial activity. In offspring mice exposed to bisphenol, an increase in colonic permeability was observed associated with an increase in interferon-γ level and a drop of colonic IgA+ cells and fecal IgA production. Interestingly, altered frequency of innate lymphoid cells type 3 occurred in the small intestine, with an increase in IgG response against commensal bacteria in sera. These effects were related to a defect in dendritic cell maturation in the lamina propria and spleen. Activated and regulatory T cells were decreased in the lamina propria. Furthermore, perinatal exposure to bisphenol promoted a sharp increase in interferon-γ and interleukin-17 production in the intestine and elicited a T helper 17 profile in the spleen. To conclude, perinatal exposure to bisphenol weakens protective and regulatory immune functions in the intestine and at systemic level in adult offspring. The increased susceptibility to inflammatory response is an interesting lead supporting bisphenol-mediated adverse consequences on food reactions and infections.
Databáze: OpenAIRE
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