cis-bis(N-benzoyl-N′,N′-dibenzylthioureido)platinum(II): Synthesis, molecular structure and its interaction with human and bovine serum albumin
| Autor: | Eduardo E. Castellano, Hiram Pérez, Ana M. Plutín, Raúl Ramos, Raúl Mocelo, Alzir A. Batista, Rodrigo S. Corrêa, Kátia de Oliveira |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Platinum complex
BSA Chemistry(all) biology Ligand Hirshfeld surface General Chemical Engineering Serum albumin chemistry.chemical_element HSA General Chemistry Crystal structure Potassium tetrachloroplatinate Binding constant lcsh:Chemistry Crystallography chemistry.chemical_compound lcsh:QD1-999 chemistry Chemical Engineering(all) biology.protein Molecule Benzoylthiourea Bovine serum albumin Platinum |
| Zdroj: | Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 3454-3462 (2019) |
| ISSN: | 1878-5352 |
| DOI: | 10.1016/j.arabjc.2015.10.006 |
| Popis: | In this paper, the title compound was synthesized from N-benzoyl-N′,N′-dibenzylthiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X‐ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N′,N′-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C–H⋯C, C–H⋯S and H⋯H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, Kb, presenting values of around 105 M−1 and 104 M−1, respectively. Thermodynamic parameters (ΔG, ΔH and ΔS) suggest spontaneous interactions between complex and the proteins. Keywords: Platinum complex, Benzoylthiourea, Hirshfeld surface, HSA, BSA |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|