Congenital clubfoot in Europe
| Autor: | Awi Wiesel, Olatz Mokoroa, Maria Loane, Amanda J. Neville, Vera Nelen, Kari Klungsøyr, Mary O'Mahony, Marie-Claude Addor, Helen Dolk, Lolkje T. W. de Jong-van den Berg, Anke Rissmann, Hermien E. K. de Walle, Linda M. Bailey, Christine Verellen-Dumoulin, Anna Pierini, Hao Wang, Ingeborg Barišić, Katarzyna Wisniewska, Ester Garne, Miriam Gatt, Babak Khoshnood |
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| Přispěvatelé: | Reproductive Origins of Adult Health and Disease (ROAHD) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pediatrics LAMOTRIGINE USE 030105 genetics & heredity Chromosomal anomaly NONSELECTED POPULATION Epidemiology EPIDEMIOLOGY Registries Genetics (clinical) associated anomalies congenital clubfoot prenatal diagnosis prevalence trend PRENATAL ULTRASOUND DETECTION RISK Stillbirth humanities Europe Clubfoot PREGNANCY Female Detection rate musculoskeletal diseases medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities IDIOPATHIC TALIPES EQUINOVARUS Large population Prenatal diagnosis Gestational Age Congenital Abnormalities 03 medical and health sciences Genetics medicine Congenital clubfoot Humans MALFORMATIONS Fetal Death Chromosome Aberrations Pregnancy business.industry Infant Newborn Infant medicine.disease OROFACIAL CLEFT Population based study 030104 developmental biology congenital lubfoot business |
| Zdroj: | American Journal of Medical Genetics. Part A American Journal of Medical Genetics. Part A, 179(4), 595-601. Wiley Wang, H, Barisic, I, Loane, M, Addor, M C, Bailey, L M, Gatt, M, Klungsoyr, K, Mokoroa, O, Nelen, V, Neville, A J, O'Mahony, M, Pierini, A, Rissmann, A, Verellen-Dumoulin, C, de Walle, H E K, Wiesel, A, Wisniewska, K, de Jong-van den Berg, L T W, Dolk, H, Khoshnood, B & Garne, E 2019, ' Congenital clubfoot in Europe : A population-based study ', American Journal of Medical Genetics. Part A, vol. 179, no. 4, pp. 595-601 . https://doi.org/10.1002/ajmg.a.61067 |
| ISSN: | 1552-4825 |
| DOI: | 10.1002/ajmg.a.61067 |
| Popis: | We aimed to assess prevalence, birth outcome, associated anomalies and prenatal diagnosis of congenital clubfoot in Europe using data from the EUROCAT network, and to validate the recording of congenital clubfoot as a major congenital anomaly by EUROCAT registries. Cases of congenital clubfoot were included from 18 EUROCAT registries covering more than 4.8 million births in 1995–2011. Cases without chromosomal anomalies born during 2005–2009, were randomly selected for validation using a questionnaire on diagnostic details and treatment. There was 5,458 congenital clubfoot cases of which 5,056 (93%) were liveborn infants. Total prevalence of congenital clubfoot was 1.13 per 1,000 births (95% CI 1.10–1.16). Prevalence of congenital clubfoot without chromosomal anomaly was 1.08 per 1,000 births (95% CI 1.05–1.11) and prevalence of isolated congenital clubfoot was 0.92 per 1,000 births (95% CI 0.90–0.95), both with decreasing trends over time and large variations in prevalence by registry. The majority of cases were isolated congenital clubfoot (82%) and 11% had associated major congenital anomalies. Prenatal detection rate of isolated congenital clubfoot was 22% and increased over time. Among 301 validated congenital clubfoot cases, diagnosis was confirmed for 286 (95%). In conclusion, this large population‐based study found a decreasing trend of congenital clubfoot in Europe after 1999–2002, an increasing prenatal detection rate, and a high standard of coding of congenital clubfoot in EUROCAT. acceptedVersion |
| Databáze: | OpenAIRE |
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