Segmental differences of cervical spinal cord motion: advancing from confounders to a diagnostic tool
| Autor: | M. Klarhoefer, Reto Sutter, C. Brockmann, Patrick Freund, S. Huwyler, Markus Hupp, Mazda Farshad, Kevin Vallotton, Jan Rosner, Armin Curt |
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| Přispěvatelé: | University of Zurich, Hupp, M |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Cord Movement Spinal cord diseases lcsh:Medicine 610 Medicine & health Article Prognostic markers 03 medical and health sciences Myelopathy 0302 clinical medicine Neuroimaging Heart rate medicine Humans Spinal canal lcsh:Science 1000 Multidisciplinary Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Magnetic resonance imaging Middle Aged medicine.disease Spinal cord Magnetic Resonance Imaging 3. Good health 030104 developmental biology medicine.anatomical_structure Neurology Spinal Cord Cervical Vertebrae Female lcsh:Q 10046 Balgrist University Hospital Swiss Spinal Cord Injury Center Radiology business 030217 neurology & neurosurgery Cervical vertebrae |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports |
| Popis: | Increased cranio-caudal spinal cord motion is associated with clinical impairment in degenerative cervical myelopathy. However, whether spinal cord motion holds potential as a neuroimaging biomarker requires further validation. Different confounders (i.e. subject characteristics, methodological problems such as phase drift, etc.) on spinal cord motion readouts have to be considered. Twenty-two healthy subjects underwent phase contrast MRI, a subset of subjects (N = 9) had repeated scans. Parameters of interest included amplitude of velocity signal, maximum cranial respectively maximum caudal velocity, displacement (=area under curve of the velocity signal). The cervical spinal cord showed pulse synchronic oscillatory motions with significant differences in all readouts across cervical segments, with a maximum at C5. The Inter-rater reliability was excellent for all readouts. The test-retest reliability was excellent for all parameters at C2 to C6, but not for maximum cranial velocity at C6 and all readouts at C7. Spinal cord motion was correlated with spinal canal size, heart rate and body size. This is the first study to propose a standardized MRI measurement of spinal cord motion for further clinical implementation based on satisfactory phase drift correction and excellent reliability. Understanding the influence of confounders (e.g. structural conditions of the spine) is essential for introducing cord motion into the diagnostic work up. |
| Databáze: | OpenAIRE |
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