Plasma antiphospholipid antibody levels in age-related macular degeneration
| Autor: | Nurşen Yüksel, Ozgul Altintas, Berna Özkan, Levent Karabaş, Yusuf Çağlar, Gülden Sönmez Tamer |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Dilute Russell's viper venom time genetic structures Enzyme-Linked Immunosorbent Assay Screen test Gastroenterology Risk Factors Geographic Atrophy Internal medicine Humans Medicine Prospective Studies Risk factor Prospective cohort study Aged Lupus anticoagulant biology business.industry General Medicine Venous blood Macular degeneration medicine.disease eye diseases Immunoglobulin Isotypes Cerebrovascular Disorders Ophthalmology Immunoglobulin M Cardiovascular Diseases Antibodies Anticardiolipin Immunoglobulin G Lupus Coagulation Inhibitor Immunology Wet Macular Degeneration biology.protein Female sense organs Antibody business |
| Zdroj: | Canadian Journal of Ophthalmology. 47:264-268 |
| ISSN: | 0008-4182 |
| DOI: | 10.1016/j.jcjo.2012.03.016 |
| Popis: | Purpose To investigate the association of age-related macular degeneration (AMD) with plasma antiphospholipid antibody levels. Methods This prospective study included 19 patients diagnosed as having dry-type AMD, 23 patients with exudative-type AMD, and 25 control subjects. Venous blood samples of the participants were obtained. Anticardiolipin antibodies (aCL) isotypes IgG and IgM were measured by means of an enzyme-linked immunosorbent assay. Lupus anticoagulant (LA) antibodies were measured by the dilute Russell viper venom time screen test. Results The mean aCL IgG concentration in patients with exudative-type AMD was significantly higher than in patients with dry-type AMD and control subjects. The mean ± SE of aCL IgG levels in patients with exudative-type AMD and dry-type AMD and control subjects was 5.46 ± 1.26; 2.55 ± 0.78; and 0.32 ± 0.1, respectively. The mean aCL IgM levels and LA levels in the 3 groups were not statistically different. Conclusions Our findings suggest that elevated levels of serum aCL, a risk factor for cardiovascular and cerebrovascular diseases, may be associated with exudative-type AMD. |
| Databáze: | OpenAIRE |
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