Abnormal Function of C-Fibers in Patients with Diabetic Neuropathy
| Autor: | Hermann O. Handwerker, Christian Weidner, Roland Schmidt, H. Erik Torebjörk, Kristin Ørstavik, Martin Schmelz, Ellen Jørum, Marita Hilliges, Barbara Namer, Richard W. Carr |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Diabetic neuropathy Neurologi Microneurography C-fibers Pain Diabetic Neuropathies Diabetes mellitus Diabetes Mellitus medicine Humans Pathological Sensitization Aged Pain Measurement Nerve Fibers Unmyelinated business.industry General Neuroscience Diabetes Articles Middle Aged medicine.disease Electric Stimulation Surgery Neuropathy medicine.anatomical_structure Touch Anesthesia Nociceptor Degeneration Female business Common peroneal nerve |
| Popis: | The mechanisms underlying the development of painful and nonpainful neuropathy associated with diabetes mellitus are unclear. We have obtained microneurographic recordings from unmyelinated fibers in eight patients with diabetes mellitus, five with painful neuropathy, and three with neuropathy without pain. All eight patients had large-fiber neuropathy, and seven patients had pathological thermal thresholds in their feet, indicating the involvement of small-caliber nerve fibers. A total of 163 C-fibers were recorded at knee level from the common peroneal nerve in the patients (36–67 years old), and these were compared with 77 C-fibers from healthy controls (41–64 years old). The ratio of mechano-responsive to mechano-insensitive nociceptors was ~2:1 in the healthy controls, whereas in the patients, it was 1:2. In patients, a fairly large percentage of characterized fibers (12.5% in nonpainful and 18.9% in painful neuropathy) resembled mechano-responsive nociceptors that had lost their mechanical and heat responsiveness. Such fibers were rarely encountered in age-matched controls (3.2%). Afferent fibers with spontaneous activity or mechanical sensitization were found in both patient groups. We conclude that small-fiber neuropathy in diabetes affects receptive properties of nociceptors that leads to an impairment of mechano-responsive nociceptors. Copyright © 2006 Society for Neuroscience |
| Databáze: | OpenAIRE |
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