Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
| Autor: | Louise Torp Dalgaard, Elisabet Børsheim, Preeti Singh, Sanjay Awasthi, Marija Petkovic, Chanda Bose, Inês N Alves, Eugenia Carvalho, Sharda P Singh, Philip Palade, Ermelindo C. Leal |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant NF-E2-Related Factor 2 Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Inflammation MMP9 medicine.disease_cause Biochemistry Antioxidants Skin Aging Mice chemistry.chemical_compound Isothiocyanates Internal medicine medicine Animals Molecular Biology Kelch-Like ECH-Associated Protein 1 Nutrition and Dietetics Cruciferous vegetables business.industry Mice Inbred C57BL Oxidative Stress Endocrinology Matrix Metalloproteinase 9 chemistry Sulfoxides Dietary Supplements Isothiocyanate medicine.symptom Reactive Oxygen Species business Oxidative stress Sulforaphane |
| Zdroj: | The Journal of Nutritional Biochemistry. 98:108817 |
| ISSN: | 0955-2863 |
| Popis: | Visible impairments in skin appearance, as well as a subtle decline in its functionality at the molecular level, are hallmarks of skin aging. Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-pathway, which is important in controlling inflammation and oxidative stress that occur during aging, can be triggered by sulforaphane (SFN), an isothiocyanate found in plants from the Brassicaceae family. This study aimed to assess the effects of SFN intake on age-related skin alterations. Male C57BL6 young (2 months) and old (21 months) mice were treated for 3 months with SFN diet (442.5 mg per kg) or control diet. The antioxidant capacities of the skin were increased in old SFN-treated animals as measured by mRNA levels of Nrf2 (P |
| Databáze: | OpenAIRE |
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