Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis
| Autor: | Robin M. Murray, Esther Setién-Suero, Victor Ortiz-García de la Foz, René S. Kahn, Simone Ciufolini, Tiago Reis Marques, Marta Di Forti, Cristina Scarpazza, Benedicto Crespo-Facorro, Anthony S. David, Neeltje E.M. van Haren, Paola Dazzan, Floor E. Scheepers, Su Lui, Sandra Vieira, Philip McGuire, Qiyong Gong, Diana Tordesillas-Gutiérrez, Andrea Mechelli, Xiaoqi Huang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
mega-analysis
Adult Male Psychosis medicine.medical_specialty Adolescent neuroanatomy Grey matter Audiology computer.software_genre 03 medical and health sciences Young Adult 0302 clinical medicine Voxel Independent samples medicine Image Processing Computer-Assisted voxel-based morphometry Humans Multi centre Gray Matter Applied Psychology Cerebral Cortex Psychiatric Status Rating Scales business.industry Brain Voxel-based morphometry Original Articles Organ Size medicine.disease First-episode psychosis Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health multi-centre medicine.anatomical_structure Psychotic Disorders Case-Control Studies Multiple comparisons problem Female business computer 030217 neurology & neurosurgery Neuroanatomy |
| Zdroj: | Psychological Medicine |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundNeuroanatomical abnormalities in first-episode psychosis (FEP) tend to be subtle and widespread. The vast majority of previous studies have used small samples, and therefore may have been underpowered. In addition, most studies have examined participants at a single research site, and therefore the results may be specific to the local sample investigated. Consequently, the findings reported in the existing literature are highly heterogeneous. This study aimed to overcome these issues by testing for neuroanatomical abnormalities in individuals with FEP that are expressed consistently across several independent samples.MethodsStructural Magnetic Resonance Imaging data were acquired from a total of 572 FEP and 502 age and gender comparable healthy controls at five sites. Voxel-based morphometry was used to investigate differences in grey matter volume (GMV) between the two groups. Statistical inferences were made at p < 0.05 after family-wise error correction for multiple comparisons.ResultsFEP showed a widespread pattern of decreased GMV in fronto-temporal, insular and occipital regions bilaterally; these decreases were not dependent on anti-psychotic medication. The region with the most pronounced decrease – gyrus rectus – was negatively correlated with the severity of positive and negative symptoms.ConclusionsThis study identified a consistent pattern of fronto-temporal, insular and occipital abnormalities in five independent FEP samples; furthermore, the extent of these alterations is dependent on the severity of symptoms and duration of illness. This provides evidence for reliable neuroanatomical alternations in FEP, expressed above and beyond site-related differences in anti-psychotic medication, scanning parameters and recruitment criteria. |
| Databáze: | OpenAIRE |
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