Coat as a Dagger: The Use of Capsid Proteins to Perforate Membranes during Non-Enveloped DNA Viruses Trafficking
| Autor: | Levon Abrahamyan, Eva Bilkova, Jitka Forstová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
viruses
viroporins lcsh:QR1-502 Review medicine.disease_cause Virus Replication papillomavirus lcsh:Microbiology Parvoviridae Cell membrane chemistry.chemical_compound Papillomaviridae biology endosome escape adenovirus membrane perforation Transmembrane protein capsid protein Cell biology Transport protein Protein Transport Infectious Diseases medicine.anatomical_structure Eukaryotic Cells Capsid coat protein Host-Pathogen Interactions Receptors Virus Polyomaviridae Protein Binding polyomavirus Endosomes Adenoviridae trafficking Virology medicine Humans cell entry Cell Nucleus Parvovirus parvovirus Cell Membrane Virus Internalization biology.organism_classification Viral replication chemistry Capsid Proteins DNA |
| Zdroj: | Viruses Viruses, Vol 6, Iss 7, Pp 2899-2937 (2014) |
| ISSN: | 1999-4915 |
| Popis: | To get access to the replication site, small non-enveloped DNA viruses have to cross the cell membrane using a limited number of capsid proteins, which also protect the viral genome in the extracellular environment. Most of DNA viruses have to reach the nucleus to replicate. The capsid proteins involved in transmembrane penetration are exposed or released during endosomal trafficking of the virus. Subsequently, the conserved domains of capsid proteins interact with cellular membranes and ensure their efficient permeabilization. This review summarizes our current knowledge concerning the role of capsid proteins of small non-enveloped DNA viruses in intracellular membrane perturbation in the early stages of infection. |
| Databáze: | OpenAIRE |
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