Placental programming of anxiety in adulthood revealed by Igf2-null models
| Autor: | Miguel Constância, Lawrence Stephen Wilkinson, Mikael Allan Mikaelsson, Claire L. Dent, Trevor Humby |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Aging
medicine.medical_specialty Placenta General Physics and Astronomy Intrauterine growth restriction Anxiety Biology Hippocampus General Biochemistry Genetics and Molecular Biology Genomic Imprinting Mice Insulin-Like Growth Factor II Pregnancy Internal medicine medicine Animals Birth Weight Maze Learning reproductive and urinary physiology Mice Knockout Regulation of gene expression Fetus Multidisciplinary Behavior Animal Body Weight Null (mathematics) Gene Expression Regulation Developmental General Chemistry medicine.disease Disease Models Animal Endocrinology medicine.anatomical_structure Acoustic Stimulation Animals Newborn embryonic structures Exploratory Behavior Gestation Female medicine.symptom |
| Zdroj: | Nature Communications. 4 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms3311 |
| Popis: | Imprinted, maternally silenced insulin-like growth factor-2 is expressed in both the foetus and placenta and has been shown to have roles in foetal and placental development in animal models. Here we compared mice engineered to be null for the placenta-specific P0 transcript (insulin-like growth factor-2-P0 KO) to mice with disruptions of all four insulin-like growth factor-2 transcripts, and therefore null for insulin-like growth factor-2 in both placenta and foetus (insulin-like growth factor-2-total KO). Both models lead to intrauterine growth restriction but dissociate between a situation where there is an imbalance between foetal demand and placental supply of nutrients (the insulin-like growth factor-2-P0 KO) and one where demand and supply is more balanced (the insulin-like growth factor-2-total KO). Increased reactivity to anxiety-provoking stimuli is manifested later in life only in those animals where there is a mismatch between placental supply and foetal demand for nutrients during gestation. Our findings further distinguish placental dysfunction from intrauterine growth restriction and reveal a role for the placenta in long-term programming of emotional behaviour. |
| Databáze: | OpenAIRE |
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