| Autor: |
Miri Adler, Noa Moriel, Aleksandrina Goeva, Inbal Avraham-Davidi, Simon Mages, Taylor S Adams, Naftali Kaminski, Evan Z Macosko, Aviv Regev, Ruslan Medzhitov, Mor Nitzan |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Most cell types in multicellular organisms can perform multiple functions. However, not all functions can be optimally performed simultaneously by the same cells. Functions incompatible at the level of individual cells can be performed at the cell population level, where cells divide labor and specialize in different functions. Division of labor can arise due to instruction by tissue environment or through self-organization. Here, we develop a computational framework to investigate the contribution of these mechanisms to division of labor within a cell-type population. By optimizing collective cellular task performance under trade-offs, we find that distinguishable expression patterns can emerge from cell-cell interactionsvs. instructive signals. We propose a method to construct ligand-receptor networks between specialist cells and use it to infer division-of-labor mechanisms from single-cell RNA-seq and spatial transcriptomics data of stromal, epithelial, and immune cells. Our framework can be used to characterize the complexity of cell interactions within tissues. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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