ECG in dilated cardiomyopathy
| Autor: | Davide Stolfo, Denise Zaffalon, Marco Merlo, Giulia Barbati, Gianfranco Sinagra, Massimo Zecchin, Stefano Bardari, Alessandro Altinier |
|---|---|
| Přispěvatelé: | Merlo, M., Zaffalon, D., Stolfo, D., Altinier, A., Barbati, G., Zecchin, M., Bardari, S., Sinagra, G. |
| Rok vydání: | 2019 |
| Předmět: |
Male
Time Factors Dilated cardiomyopathy Cardiomyopathy Arrhythmic stratification Predictive Value of Test Arrhythmias 030204 cardiovascular system & hematology Left ventricular hypertrophy Electrocardiography 0302 clinical medicine Long-term Retrospective Studie Heart Rate Risk Factors Dilated 030212 general & internal medicine medicine.diagnostic_test Description General Medicine Middle Aged Prognosis Death Predictive value of tests Cardiology Female Cardiology and Cardiovascular Medicine Cardiac Human Adult Cardiomyopathy Dilated medicine.medical_specialty Time Factor Prognosi Sudden death ECG Arrhythmias Cardiac Death Sudden Cardiac Heart Transplantation Humans Predictive Value of Tests Retrospective Studies 03 medical and health sciences Internal medicine Heart rate medicine cardiovascular diseases business.industry Risk Factor Retrospective cohort study medicine.disease Sudden business |
| Zdroj: | Journal of Cardiovascular Medicine. 20:450-458 |
| ISSN: | 1558-2027 |
| Popis: | Objective The objective was to provide an exhaustive characterization of ECG features in a large cohort of dilated cardiomyopathies (DCMs) and then investigate their possible prognostic role in the long term. Background ECG is an accessible, reproducible, low-cost diagnostic and prognostic tool. However, an extensive description of ECG features and their long-term prognostic role in a large cohort of DCM is lacking. Methods All available baseline ECGs of DCM patients enrolled from 1992 to 2013 were systematically analysed. Patients underwent to a complete clinical-laboratory evaluation. The study outcome measures were death or heart transplant (D/HT) and sudden death or malignant ventricular arrhythmias (SD/MVA). Results Four hundred and fourteen DCM patients were enrolled. During a median follow-up of 125 months, 55 and 57 patients experienced D/HT and SD/MVA, respectively. At multivariate analysis, left ventricular hypertrophy (P = 0.017), heart rate (HR, P = 0.005) and anterolateral T-wave inversion (P = 0.041) predicted D/HT. Regarding SD/MVA, S wave amplitude in V2 (P = 0.008), R wave amplitude in DIII (P = 0.007), anterolateral T-wave inversion (P = 0.017) emerged as predictors. At receiver-operating curve analyses, the addition of ECG models to the clinical-laboratory evaluation significantly increased the area under the curve both for D/HT (from 0.68 to 0.74, P = 0.042) and SD/MVA (from 0.70 to 0.77, P = 0.048). Conclusion The exhaustive systematic evaluation of ECG has an incremental impact in the prognostication of a large cohort of DCM patients, also regarding the arrhythmic stratification. |
| Databáze: | OpenAIRE |
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