Autophagy: novel applications of nonsteroidal anti-inflammatory drugs for primary cancer
| Autor: | Chen Yu, Jun‐bao Liu, Jifeng Feng, Wei-bing Li, Jian-wei Lu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway Cancer Research Programmed cell death Reviews Apoptosis Review Phosphatidylinositol 3-Kinases 03 medical and health sciences Cell Line Tumor Neoplasms Lysosome Autophagy medicine Humans Radiology Nuclear Medicine and imaging programmed cell death Endoplasmic Reticulum Chaperone BiP Protein kinase B PI3K/AKT/mTOR pathway Cancer Biology Sulindac business.industry TOR Serine-Threonine Kinases Anti-Inflammatory Agents Non-Steroidal nonsteroidal anti‐inflammatory drugs 030104 developmental biology medicine.anatomical_structure Oncology Cancer cell Cancer research business Proto-Oncogene Proteins c-akt Signal Transduction medicine.drug |
| Zdroj: | Cancer Medicine |
| ISSN: | 2045-7634 |
| DOI: | 10.1002/cam4.1287 |
| Popis: | In eukaryotic cells, autophagy is a process associated with programmed cell death. During this process, cytoplasmic proteins and organelles are engulfed by double‐membrane autophagosomes, which then fuse with lysosomes to form autolysosomes. These autolysosomes then degrade their contents to recycle the cellular components. Autophagy has been implicated in a wide variety of physiological and pathological processes that are closely related to tumorigenesis. In recent years, an increasing number of studies have indicated that nonsteroidal anti‐inflammatory drugs, such as celecoxib, meloxicam, sulindac, aspirin, sildenafil, rofecoxib, and sodium salicylate, have diverse effects in cancer that are mediated by the autophagy pathway. These nonsteroidal anti‐inflammatory drugs can modulate tumor autophagy through the PI3K/Akt/mTOR, MAPK/ERK1/2, P53/DRAM, AMPK/mTOR, Bip/GRP78, CHOP/ GADD153, and HGF/MET signaling pathways and inhibit lysosome function, leading to p53‐dependent G1 cell‐cycle arrest. In this review, we summarize the research progress in autophagy induced by nonsteroidal anti‐inflammatory drugs and the molecular mechanisms of autophagy in cancer cells to provide a reference for the potential benefits of nonsteroidal anti‐inflammatory drugs in cancer chemotherapy. |
| Databáze: | OpenAIRE |
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