| Autor: |
Lagiou,Olga, Fouzas,Sotirios, Lykouras,Dimosthenis, Sinopidis,Xenophon, Karatza,Aggeliki, Karkoulias,Kiriakos, Dimitriou,Gabriel, Anthracopoulos,Michael B |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Asthma and Allergy |
| ISSN: |
1178-6965 |
| Popis: |
Background Children with uncontrolled asthma are less tolerant to exercise due to ventilatory limitation, exercise-induced bronchoconstriction (EIB), or physical deconditioning. The contribution of these factors in children with controlled mild-to-moderate asthma is unknown. Objective To explore the underlying mechanisms of reduced exercise capacity in children with controlled mild-to-moderate asthma. Methods This was a cross-sectional study of 45 children and adolescents (age 8–18 years) with controlled mild-to-moderate asthma (asthma control test score 21–25) and 61 age-matched healthy controls. All participants completed a physical activity questionnaire and performed spirometry and cardiopulmonary exercise testing (CPET; maximal incremental protocol). Spirometric indices and CPET parameters were compared between the two groups. The effect of EIB (FEV1 decrease >10% post CPET), ventilatory limitation and physical deconditioning on maximum oxygen uptake (\documentclass[12pt]{minimal} \usepackage{wasysym} \usepackage[substack]{amsmath} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage[mathscr]{eucal} \usepackage{mathrsfs} \DeclareFontFamily{T1}{linotext}{} \DeclareFontShape{T1}{linotext}{m}{n} {linotext }{} \DeclareSymbolFont{linotext}{T1}{linotext}{m}{n} \DeclareSymbolFontAlphabet{\mathLINOTEXT}{linotext} \begin{document} $${\mathop {\rm{V}}\limits^.}$$ \end{document}O2peak), was assessed by multivariable linear regression. Results 62.2% of children with asthma and 29.5% of controls (P = 0.002) were categorized as inactive. Reduced exercise capacity (\documentclass[12pt]{minimal} \usepackage{wasysym} \usepackage[substack]{amsmath} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage[mathscr]{eucal} \usepackage{mathrsfs} \DeclareFontFamily{T1}{linotext}{} \DeclareFontShape{T1}{linotext}{m}{n} {linotext }{} \DeclareSymbolFont{linotext}{T1}{linotext}{m}{n} \DeclareSymbolFontAlphabet{\mathLINOTEXT}{linotext} \begin{document} $${\mathop {\rm{V}}\limits^.}$$ \end{document}O2peak |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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