Neurotropic Threat Characterization of Burkholderia pseudomallei Strains
| Autor: | Bart J. Currie, Jodie L. Morris, Catherine M. Rush, Mark Mayo, Natkunam Ketheesan, Anne Fane, Brenda Govan |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Adult Central Nervous System Male Melioidosis Burkholderia pseudomallei bioterrorism Adolescent Epidemiology Neurotropism Virulence lcsh:Medicine Disease Biology Microbiology lcsh:Infectious and parasitic diseases Young Adult Central Nervous System Bacterial Infections medicine Animals Humans lcsh:RC109-216 bacteria Aged Mice Inbred BALB C Experimental model Mortality rate Research neurologic lcsh:R neurotropism Neurotropic Threat Characterization of Burkholderia pseudomallei Strains Middle Aged biology.organism_classification medicine.disease Bacterial Load Mice Inbred C57BL Infectious Diseases C57BL Mouse Immunology Female route of infection |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 21, Iss 1, Pp 58-63 (2015) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Unique virulence factors of certain strains facilitate central nervous system invasion, regardless of infection route. The death rate for neurologic melioidosis is high. Whether certain Burkholderia pseudomallei strains are more likely than other strains to cause central nervous system infection and whether route of infection influences the neurotropic threat remain unclear. Therefore, we compared the virulence and dissemination of Australian clinical isolates collected during October 1989–October 2012 from patients with neurologic and nonneurologic melioidosis after intranasal and subcutaneous infection of mice in an experimental model. We did not observe neurotropism as a unique characteristic of isolates from patients with neurologic melioidosis. Rather, a distinct subset of B. pseudomallei strains appear to have heightened pathogenic potential for rapid dissemination to multiple tissues, including the central nervous system, irrespective of the infection route. This finding has valuable public health ramifications for initiating appropriate and timely therapy after exposure to systemically invasive B. pseudomallei strains. Increasing understanding of B. pseudomallei pathology and its influencing factors will further reduce illness and death from this disease. |
| Databáze: | OpenAIRE |
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