Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur: comparison with the bisindolylmaleimide arcyriarubin A
| Autor: | Peter Mayser, Rolf-Hasso Bödeker, Dino Kessler, Ute-Christina Hipler, Wiebke Hort, Hans-Joachim Krämer, Bernhard Irlinger, Wolfgang Steglich |
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| Rok vydání: | 2005 |
| Předmět: |
Bisindolylmaleimide
Indoles Neutrophils Human skin Biology Biochemistry Microbiology Indole Alkaloids Maleimides chemistry.chemical_compound Tinea Versicolor medicine Humans Protein kinase A Molecular Biology Mycosis Respiratory Burst Indole test Arachidonate 5-Lipoxygenase Malassezia integumentary system Organic Chemistry Pityriasis medicine.disease Yeast Respiratory burst chemistry Molecular Medicine |
| Zdroj: | Chembiochem : a European journal of chemical biology. 6(12) |
| ISSN: | 1439-4227 |
| Popis: | Pityriasis versicolor is the most common skin mycosis in humans worldwide. Yeasts of the genus Malassezia, particularly M. furfur, a saprophyte occurring widely on human skin, are generally regarded as the causative agents. M. furfur is able to convert tryptophan into a variety of indole alkaloids, some of them showing biological properties that correlate well with certain clinical features of pityriasis versicolor. This suggests a possible role for these compounds in the pathophysiology of the disease. We here report that the novel pityriarubins A, B and C, isolated from cultures of the yeast, inhibit respiratory burst in human neutrophils, activated by various agents, in a highly selective, unexpected manner. The release of 5-lipoxygenase products after challenge of neutrophils with the calcium ionophore A23187 is also inhibited in a dose-dependent manner. These activities reflect the close structural relationship of pityriarubins to bisindolylmaleimides, which have recently gained great interest as protein kinase inhibitors. |
| Databáze: | OpenAIRE |
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