Enantioenriched 1-Tetralones via Rhodium-Catalyzed Arylative Cascade Desymmetrization/Acylation of Alkynylmalonates
| Autor: | Sylvain Darses, Aymane Selmani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Diene 010405 organic chemistry Organic Chemistry Regioselectivity Alkyne 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Desymmetrization 0104 chemical sciences Stereocenter Acylation chemistry.chemical_compound chemistry Moiety Physical and Theoretical Chemistry Tetralones |
| Zdroj: | Organic Letters. 21:8122-8126 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | An efficient atom-economic rhodium-catalyzed asymmetric arylative cyclization to access enantioenriched 1-tetralones, bearing a quaternary carbon stereocenter, is described, involving a highly regioselective alkyne insertion, a 1,4-Rh shift, and an acylation step via the desymmetrization of the malonate moiety thanks to an appropriate chiral diene ligand. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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