Evaluation of possible subclinical atherosclerosis in adolescents with a family history of premature atherosclerosis
| Autor: | Fatih Koç, Zekiye Ruken Yuksekkaya Celikyay, İbrahim Halil Damar, Atac Celik, Yasemin Yerli, Unal Erkorkmaz, Köksal Ceyhan, Mustafa Özçetin, Hasan Kadi, Erkan Söğüt |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Heredity Homocysteine Adolescent Turkey Coronary Artery Disease Carotid Intima-Media Thickness Risk Assessment Coronary artery disease chemistry.chemical_compound Fathers Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Family history Age of Onset Pulse wave velocity Aorta Echocardiography Doppler Pulsed business.industry Premature coronary artery disease Small sample medicine.disease Elasticity Pedigree Premature atherosclerosis C-Reactive Protein Carotid Arteries Phenotype chemistry Subclinical atherosclerosis Case-Control Studies Pulsatile Flow Asymptomatic Diseases cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Atherosclerosis. 222(2) |
| ISSN: | 1879-1484 |
| Popis: | Objective To evaluate possible subclinical atherosclerosis using biomarkers and ultrasound-guided methods in a group of adolescents having fathers with premature atherosclerosis. Methods Thirty-three subjects whose fathers had a history of premature coronary artery disease and 30 counterparts whose fathers had no history of coronary artery disease were included in the study. Results The homocysteine levels, high-sensitivity C-reactive protein levels, and cardiac chamber sizes and functions did not differ between the two groups. The carotid stiffness index β (CSI), the intima-media thickness (CIMT) and aortic pulse wave velocity (PWV) values were higher in the group with a family history of coronary artery disease, but only the difference in the CSI was statistically significant (CSI 3.07±1.33 vs 3.88±1.25, P =0.015; CIMT 0.53±0.09mm vs 0.57±0.08mm, P =0.068; PWV 3.49±0.53m/s vs 3.78±0.63m/s, P =0.053). Conclusion Among several markers of subclinical atherosclerosis, the CSI was significantly higher in adolescents who had a family history of premature atherosclerosis. The small sample size, the multifactorial nature of atherosclerosis or the insufficient power of these methods may explain these results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect