REACH, non-testing approaches and the urgent need for a change in mind set
| Autor: | E.D. Kroese, Erik Tielemans, C.J. Van Leeuwen, Gerwin Schaafsma, J.J.M. van de Sandt |
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| Přispěvatelé: | TNO Kwaliteit van Leven |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
reproductive toxicity
Databases Factual environmental exposure Hazard analysis acute toxicity Toxicology Intelligent testing strategies cost REACH program Registries uncertainty Mind set change Management science Uncertainty paradox article General Medicine Environmental exposure Hazard Europe Chemistry Risk analysis (engineering) chemical agent priority journal health care policy Chemical agents Risk assessment Process (engineering) Food and Chemical Risk Analysis Animal Testing Alternatives Risk Assessment Hazardous Substances hazard assessment in vivo study Time frame toxicity testing process optimization Toxicity Tests Animals Humans Animalia drug screening human Set (psychology) skin toxicity human tissue animal testing alternative public opinion Non-testing REACH chronic toxicity |
| Zdroj: | Regulatory Toxicology and Pharmacology, 1, 53, 70-80 |
| Popis: | The objectives of REACH cannot be achieved under the current risk assessment approach. A change in mind set among all the relevant stakeholders is needed: risk assessment should move away from a labor-intensive and animal-consuming approach to intelligent and pragmatic testing, by combining exposure and hazard data effectively and trying to group chemicals (category approaches). The focus should be on reducing the overall uncertainties of 30,000 chemicals while acknowledging the existence of the uncertainty paradox: reducing uncertainty in the assessment of individual chemicals following the classical chemical-by-chemical approach as we have in previous decades will result in a prolongation of uncertainty for the entire group of 30,000 chemicals as a whole. With the first REACH registration deadline (2010) rapidly approaching, a mind set change is urgently needed. We can speed up the regulatory acceptance process, starting with the maximum use of currently available exposure and hazard data, tools and models. Optimal use should also be made of experimental exposure and hazard data generated under REACH. Only such an approach will make it possible to obtain a sufficient level of information within the time frame of REACH. A much more intensive dialogue between stakeholders is necessary. © 2008 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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