Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: Implications for treatment
Autor: | Donald C. McMillan, Antonia K. Roseweir, Joanne Edwards, Kathryn Af Pennel, James H. Park |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Colorectal cancer Cell Anti-Inflammatory Agents Inflammation 03 medical and health sciences 0302 clinical medicine Immune system Tumor Microenvironment Humans Medicine Gastrointestinal cancer business.industry Cell growth Carcinoma Cancer Cell Biology medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Signal transduction medicine.symptom Colorectal Neoplasms business |
Zdroj: | Cellular Signalling. 54:81-90 |
ISSN: | 0898-6568 |
Popis: | Over the last 15 years there has been a change in how we understand the impact of the interaction between the tumour and the host on cancer outcomes. From the simplistic view that the make-up of tumours cells largely determines their aggressiveness to a more complex view that the interaction between the products of tumour and host cell signal transduction pathways is crucial in determining whether the tumour cell is eliminated or survives in the host. Of the host cells, those with an immune/inflammatory function are most well documented to inhibit or promote tumour cell proliferation and dissemination. It is only in the last few years that there has been greater recognition of the impact of intracellular, cellular and systemic immune/inflammatory phenotypes on patient outcomes independent of current tumour staging and that these phenotypes are useful in informing oncological research and practice. In the present review we will examine the importance of inflammatory phenotypes at the intra-cellular, cellular and systemic levels on outcomes in patients with gastrointestinal cancer with focus on colorectal cancer. Based on these phenotypes we will examine and discuss the prospects for therapeutic intervention. |
Databáze: | OpenAIRE |
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