Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role
| Autor: | Anne F. Buckley, Maureen Petersen, Giselle Y. Lopez, Thomas J. Cummings, Janice S Ahn, Allan H. Friedman, Edward M López |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Ependymoma Male Pathology medicine.medical_specialty Cell type Ependymal Cell Adolescent Posterior fossa EOSINOPHILIC GLOBULES Infratentorial Neoplasms Pathology and Forensic Medicine law.invention 03 medical and health sciences 0302 clinical medicine Structural Biology law medicine Humans Chemistry medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Ultrastructure Electron microscope Subcommissural organ |
| Zdroj: | Ultrastructural pathology. 44(4-6) |
| ISSN: | 1521-0758 |
| Popis: | A number of neoplasms of the central nervous system can demonstrate diffuse eosinophilic globules, known to be secretory products of the corresponding cell type, but they have not been a salient feature in descriptions of classic ependymoma. Here, we present a case of a posterior fossa ependymoma demonstrating glassy PAS-positive, diastase-resistant, eosinophilic globules with light microscopic and ultrastructural features resembling Reissner fiber, the secretory product of the subcommissural organ. While there has been a single published description of an ependymoma with intra- and extracellular granulofibrillary material suggested to be evidence of secretory differentiation, ours is the first case to demonstrate diffuse eosinophilic globules in an ependymoma. The extent of globules allowed full study by electron microscopy to provide new insight into the secretory material and the surrounding structures. Our findings suggest that neoplastic ependymal cells can recapitulate the secretory capacity of the subcommissural organ. |
| Databáze: | OpenAIRE |
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