The lipid peroxidation end-product and oxidant 4-hydroxynonenal induces insulin resistance in rat slow-twitch skeletal muscle

Autor: Erik J. Henriksen, Mujalin Prasannarong, Franchesca J. Giovannini, Payam Hooshmand, Fernando R. Santos, Paria Hooshmand
Rok vydání: 2013
Předmět:
Zdroj: Archives of Physiology and Biochemistry. 120:22-28
ISSN: 1744-4160
1381-3455
DOI: 10.3109/13813455.2013.834937
Popis: Context: The lipid peroxidation end-product and oxidant 4-hydroxynonenal (4-HNE) impairs cell function. However, the impact of 4-HNE on the glucose transport system in mammalian slow-twitch skeletal muscle is not known. Objective: We assessed the effects of 4-HNE on insulin signalling and glucose transport activity in slow-twitch muscle by incubating soleus strips from lean Zucker rats with 4-HNE (50 µM) in the absence or presence of insulin (5 mU/ml) for up to 6 hr. Results: Insulin-stimulated glucose transport activity was significantly (p
Databáze: OpenAIRE