The lipid peroxidation end-product and oxidant 4-hydroxynonenal induces insulin resistance in rat slow-twitch skeletal muscle
Autor: | Erik J. Henriksen, Mujalin Prasannarong, Franchesca J. Giovannini, Payam Hooshmand, Fernando R. Santos, Paria Hooshmand |
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Rok vydání: | 2013 |
Předmět: |
medicine.medical_specialty
Physiology medicine.medical_treatment In Vitro Techniques 4-Hydroxynonenal Lipid peroxidation chemistry.chemical_compound Insulin resistance Physiology (medical) Internal medicine medicine Animals Phosphorylation Muscle Skeletal Protein kinase B Soleus muscle Aldehydes Insulin GTPase-Activating Proteins Glucose transporter Skeletal muscle Biological Transport General Medicine Oxidants medicine.disease Rats Rats Zucker Glucose medicine.anatomical_structure Endocrinology Gene Expression Regulation chemistry Insulin Receptor Substrate Proteins Female Lipid Peroxidation Insulin Resistance Proto-Oncogene Proteins c-akt Signal Transduction |
Zdroj: | Archives of Physiology and Biochemistry. 120:22-28 |
ISSN: | 1744-4160 1381-3455 |
DOI: | 10.3109/13813455.2013.834937 |
Popis: | Context: The lipid peroxidation end-product and oxidant 4-hydroxynonenal (4-HNE) impairs cell function. However, the impact of 4-HNE on the glucose transport system in mammalian slow-twitch skeletal muscle is not known. Objective: We assessed the effects of 4-HNE on insulin signalling and glucose transport activity in slow-twitch muscle by incubating soleus strips from lean Zucker rats with 4-HNE (50 µM) in the absence or presence of insulin (5 mU/ml) for up to 6 hr. Results: Insulin-stimulated glucose transport activity was significantly (p |
Databáze: | OpenAIRE |
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