Effect of hyperkalemia on insulin secretion
| Autor: | Barbara Rietberg, G. Perez, R. Martinez, Jay S. Skyler, J. R. Oster |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Hyperkalemia medicine.medical_treatment Potassium chemistry.chemical_element Cellular and Molecular Neuroscience Dogs Internal medicine Insulin Secretion Carnivora medicine Animals Insulin Secretion Molecular Biology Pancreatic hormone Pharmacology biology business.industry Fissipedia Cell Biology biology.organism_classification Peripheral Endocrinology chemistry Molecular Medicine Female medicine.symptom business |
| Zdroj: | Experientia. 47:270-272 |
| ISSN: | 1420-9071 0014-4754 |
| Popis: | The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68 +/- 0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p less than 0.05). We concluded that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink