Stabilization of Oxidative Stress 1 Year after Kidney Transplantation: Effect of Calcineurin Immunosuppressives

Autor:	Petr Schneiderka, Adéla Galandáková, Josef Zadražil, Pavel Štrebl, Jitka Vostálová, Alena Rajnochová Svobodová, Jana Zapletalová, Markéta Kajabová
Rok vydání:	2012
Předmět:	Adult Male medicine.medical_specialty Renal function Kidney Kidney Function Tests Critical Care and Intensive Care Medicine Lipid peroxidation chemistry.chemical_compound Internal medicine Humans Medicine Prospective Studies Renal Insufficiency Chronic Kidney transplantation chemistry.chemical_classification Creatinine business.industry Calcineurin Glutathione peroxidase Kidney metabolism General Medicine Middle Aged Prognosis medicine.disease Kidney Transplantation Oxidative Stress Treatment Outcome Endocrinology medicine.anatomical_structure chemistry Nephrology Female business Biomarkers Immunosuppressive Agents Glomerular Filtration Rate
Zdroj:	Renal Failure. 34:952-959
ISSN:	1525-6049 0886-022X
DOI:	10.3109/0886022x.2012.699874
Popis:	Kidney transplantation (KT) is one of the best treatments for patients with chronic renal disease. It leads to improved kidney function, but the oxidative stress (OS) is only partially eliminated after KT. This study evaluated the effect of KT on outcomes, such as (a) specific kidney functions, (b) metabolic parameters, as well as (c) OS-related markers in 70 patients (46 males, 24 females; mean age = 54 ± 11) before and 1 year after KT. Post KT, the patients were divided into two groups: those receiving only cyclosporine A (N = 36) and those receiving only tacrolimus (N = 34). Improved kidney function (creatinine, urea, and glomerular filtration rate) and biochemical and hematological parameters were found 1 year after KT. OS-related markers (total antioxidant capacity, advanced oxidation protein, and lipid peroxidation products) decreased, but glutathione level increased after KT. Alterations in superoxide dismutase and catalase activities were also found. Glutathione peroxidase levels were unchanged. The level of oxidized low-density lipoprotein was surprisingly, not significantly increased. There was no significant difference between calcineurin inhibitors in any of the measured parameters. Improved renal function after KT is linked to reduction in OS but independent of immunosuppressive therapy.
Databáze:	OpenAIRE
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