Choice of an ovarian stimulation protocol according to the follicular puncture method in an in vitro fertilization programme
| Autor: | Marie-France Sarramon, Xavier Monrozies, Reme Jm, G. Pontonnier, J. Parinaud, Christine Sarrazin, Hélène Grandjean |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
endocrine system
medicine.medical_specialty Menotropins medicine.medical_treatment Stimulation Fertilization in Vitro Punctures Clomiphene Ovarian Follicle Ovulation Induction Clomifene Follicular phase medicine Humans Pelvic examination Gynecology In vitro fertilisation biology medicine.diagnostic_test business.industry Obstetrics and Gynecology Oocyte medicine.anatomical_structure Reproductive Medicine HMG-CoA reductase Oocytes biology.protein Female Test protocol business medicine.drug |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 24:285-292 |
| ISSN: | 0301-2115 |
| Popis: | In order to ascertain the adequacy of ovarian stimulation protocols with a type of follicular puncture, 126 women undergoing in vitro fertilization received either combination clomiphene/hMG or hMG alone according to a randomized test protocol. Within both groups patients for whom a pelvic examination was required had laparoscopies, while others had transvaginal ultrasonically guided punctures as far as possible. Clomiphene/hMG was more efficient than hMG alone as assessed from the cleavage rate (68% vs. 54%; p less than 0.01) and the pregnancy per attempt rate (16% vs. 5%; p less than 0.05). Laparoscopic punctures were more efficient than ultrasonically guided punctures (mean number of recovered oocytes: 4.8 +/- 2.6 vs. 3 +/- 2.5; p less than 0.001), but slightly better results were achieved by this latter method in ongoing pregnancy per puncture rate (18% vs. 8%; NS). With ultrasonically guided punctures, stimulation by clomiphene/hMG allowed better oocyte recoveries (3.8 +/- 2.5 vs. 2.3 +/- 1.9, p less than 0.05). Such results constitute an argument for preferential use of the clomiphene/hMG stimulation protocol with ultrasonically guided punctures. |
| Databáze: | OpenAIRE |
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