cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits
| Autor: | Roseann F. Titcombe, Edward B. Ziff, Shannon O. Antoine, Sinedu Abera, David S. Tukey, Loren M. DeVito, Charles A. Hoeffer, Sarah A. Vunck, Yoon Choi, Natasha N. Tirko, Franz Hofmann, Charlotte M. Wincott |
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| Rok vydání: | 2014 |
| Předmět: |
Mice
Knockout Radial arm maze Behavior Animal Cognitive Neuroscience Morris water navigation task Experimental and Cognitive Psychology Cyclic GMP-Dependent Protein Kinase Type II AMPA receptor Anxiety Article Marble burying Mice Behavioral Neuroscience Memory Short-Term Animals NMDA receptor Phosphorylation Maze Learning Prefrontal cortex Psychology Postsynaptic density Neuroscience cGMP-dependent protein kinase |
| Zdroj: | Neurobiology of Learning and Memory. 114:32-39 |
| ISSN: | 1074-7427 |
| DOI: | 10.1016/j.nlm.2014.04.007 |
| Popis: | Neuronal activity regulates AMPA receptor trafficking, a process that mediates changes in synaptic strength, a key component of learning and memory. This form of plasticity may be induced by stimulation of the NMDA receptor which, among its activities, increases cyclic guanosine monophosphate through the nitric oxide synthase pathway. cGMP-dependent protein kinase type II (cGKII) is ultimately activated via this mechanism and AMPA receptor subunit GluA1 is phosphorylated at serine 845. This phosphorylation contributes to the delivery of GluA1 to the synapse, a step that increases synaptic strength. Previous studies have shown that cGKII-deficient mice display striking spatial learning deficits in the Morris Water Maze compared to wild-type littermates as well as lowered GluA1 phosphorylation in the postsynaptic density of the prefrontal cortex (Serulle, Zhang, Ninan, Puzzo, McCarthy, Khatri, Arancio, and Ziff, 2007; Wincott, Kim, Titcombe, Tukey, Girma, Pick, Devito, Hofmann, Hoeffer, and Ziff, 2013). In the current study, we show that cGKII knockout mice exhibit impaired working memory as determined using the prefrontal cortex-dependent Radial Arm Maze (RAM). Additionally, we report reduced repetitive behavior in the Marble Burying task (MB), and heightened anxiety-like traits in the Novelty Suppressed Feeding Test (NSFT). These data suggest that cGKII may play a role in the integration of information that conveys both anxiety-provoking stimuli as well as the spatial and environmental cues that facilitate functional memory processes and appropriate behavioral response. |
| Databáze: | OpenAIRE |
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