Renal tubular function in horses during submaximal exercise
| Autor: | L. M. Schmall, William W. Muir, Kenneth W. Hinchcliff, K. H. McKeever |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Time Factors Physiology Physical Exertion Renal function Blood Pressure Physical exercise Urine Kidney Function Tests Plasma renin activity Excretion Electrolytes chemistry.chemical_compound Atrial natriuretic peptide Physiology (medical) Internal medicine Renin medicine Animals Horses Aldosterone Chemistry Arginine Vasopressin Plasma osmolality Free water clearance Kidney Tubules Endocrinology Creatinine Female Atrial Natriuretic Factor |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 261:R553-R560 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.1991.261.3.r553 |
| Popis: | Exercise-induced changes in renal function were examined during steady-state submaximal treadmill exercise in six unfit mares. Horses were randomly assigned to either an exercise or parallel control (no exercise) trial on day 1 and the alternate trial 1 wk later. The mares ran on a treadmill, set at a 6 degrees incline, for 1 h at 55-60% of maximal heart rate. Exercise significantly (P less than 0.05) increased plasma osmolality, plasma [K+], urine flow (+ 45%), Na+ excretion (+ 371%), K+ excretion (+ 57%), osmotic clearance (+ 32%), Na+ clearance (+ 391%), K+ clearance (+ 33%), and fractional Na+ excretion (+ 320%) and significantly decreased plasma [Cl-], Cl- excretion (-46%), Cl- clearance (-41%), and fractional Cl- excretion (-47%). Glomerular filtration rate, fractional K+ excretion, and free water clearance did not change during exercise. Atrial natriuretic peptide increased during exercise from 11 +/- 1 pg/ml at rest to a peak of 40 +/- 9 pg/ml (264%, P less than 0.05) at 40 min. Increases in plasma renin activity (66%, P less than 0.05) were accompanied by increases in plasma aldosterone concentration (760%, P less than 0.05). Vasopressin concentration increased (P less than 0.05) steadily over the 60-min period of exercise. It was concluded that, in horses, submaximal exercise-induced increases in urine flow and sodium excretion are associated with a concurrent increase in the plasma concentration of atrial natriuretic peptide. |
| Databáze: | OpenAIRE |
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