Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies
| Autor: | Krista S. Crider, Amy M Cordero, Robert J. Berry, Heather C. Hamner, Jing Guo, Yan Ping Qi, Becky L. Tsang, Joseph Mulinare, Owen Devine, Jorge Rosenthal, Claire M. Marchetta, Patricia Mersereau |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Databases Factual Genotype Population Medicine (miscellaneous) Sensitivity and Specificity Gastroenterology Young Adult Folic Acid Risk Factors Internal medicine medicine Humans Mthfr c677t Neural Tube Defects Child education Alleles Methylenetetrahydrofolate Reductase (NADPH2) Randomized Controlled Trials as Topic education.field_of_study Polymorphism Genetic Nutrition and Dietetics biology business.industry Blood folate Editorials Middle Aged Observational Studies as Topic Red blood cell medicine.anatomical_structure Meta-analysis Methylenetetrahydrofolate reductase biology.protein Female RBC Folate business |
| Zdroj: | The American Journal of Clinical Nutrition. 101:1286-1294 |
| ISSN: | 0002-9165 |
| DOI: | 10.3945/ajcn.114.099994 |
| Popis: | BACKGROUND The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural tube defects. The T allele produces an enzyme with reduced folate-processing capacity, which has been associated with lower blood folate concentrations. OBJECTIVE We assessed the association between MTHFR C677T genotypes and blood folate concentrations among healthy women aged 12-49 y. DESIGN We conducted a systematic review of the literature published from January 1992 to March 2014 to identify trials and observational studies that reported serum, plasma, or red blood cell (RBC) folate concentrations and MTHFR C677T genotype. We conducted a meta-analysis for estimates of percentage differences in blood folate concentrations between genotypes. RESULTS Forty studies met the inclusion criteria. Of the 6 studies that used the microbiologic assay (MA) to measure serum or plasma (S/P) and RBC folate concentrations, the percentage difference between genotypes showed a clear pattern of CC > CT > TT. The percentage difference was greatest for CC > TT [S/P: 13%; 95% credible interval (CrI): 7%, 18%; RBC: 16%; 95% CrI: 12%, 20%] followed by CC > CT (S/P: 7%; 95% CrI: 1%, 12%; RBC: 8%; 95% CrI: 4%, 12%) and CT > TT (S/P: 6%; 95% CrI: 1%, 11%; RBC: 9%; 95% CrI: 5%, 13%). S/P folate concentrations measured by using protein-binding assays (PBAs) also showed this pattern but to a greater extent (e.g., CC > TT: 20%; 95% CrI: 17%, 22%). In contrast, RBC folate concentrations measured by using PBAs did not show the same pattern and are presented in the Supplemental Material only. CONCLUSIONS Meta-analysis results (limited to the MA, the recommended population assessment method) indicated a consistent percentage difference in S/P and RBC folate concentrations across MTHFR C677T genotypes. Lower blood folate concentrations associated with this polymorphism could have implications for a population-level risk of neural tube defects. |
| Databáze: | OpenAIRE |
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