Homologous recombination within repetitive DNA
| Autor: | Catherine H. Freudenreich, Erica J Polleys |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
DNA Replication
DNA Repair DNA damage DNA replication DNA Break-Induced Replication Biology Genomic Instability Article Cell biology chemistry.chemical_compound chemistry Genetics Humans Microsatellite Homologous Recombination Repeated sequence Homologous recombination Recombination DNA Damage Developmental Biology |
| Zdroj: | Curr Opin Genet Dev |
| ISSN: | 0959-437X |
| Popis: | Many microsatellite DNA sequences are able to form non-B form DNA secondary structures, such as hairpin loops, cruciforms, triplex DNA or G-quadruplexes. These DNA structures can form a significant impediment to DNA replication and repair, leading to DNA nicks, gaps, and breaks, which can be repaired by homologous recombination (HR). Recent work understanding HR at structure-forming repeats has focused on genetic requirements for replication fork restart, break induced replication (BIR) at broken forks, recombination during and after relocalization of breaks or stalled forks to the nuclear periphery, and how repair pathway choice and kinetics are navigated in the presence of a repeat tract. In this review, we summarize recent developments that illuminate the role of recombination in repairing DNA damage or causing tract length changes within repetitive DNA and its role in maintaining genome stability. |
| Databáze: | OpenAIRE |
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