The role of complement in Alzheimer’s disease pathology
| Autor: | Mark R. Emmerling, M. Desiree Watson, Katharyn Spiegel, Charlotte Raby |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Serine Proteinase Inhibitors
Molecular Sequence Data Inflammation Biology Amyloid beta-Protein Precursor β-Amyloid peptide Alzheimer Disease mental disorders medicine Animals Humans Dementia Cyclooxygenase Inhibitors Amino Acid Sequence Neurodegeneration Complement Activation Molecular Biology Amyloid beta-Peptides Binding Sites Microglia Anti-Inflammatory Agents Non-Steroidal P3 peptide Brain Complement System Proteins medicine.disease Peptide Fragments Biochemistry of Alzheimer's disease Complement system Complement (complexity) Disease Models Animal medicine.anatomical_structure Astrocytes Immunology Molecular Medicine medicine.symptom |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1502(1):158-171 |
| ISSN: | 0925-4439 |
| DOI: | 10.1016/s0925-4439(00)00042-9 |
| Popis: | Complement proteins are integral components of amyloid plaques and cerebral vascular amyloid in Alzheimer brains. They can be found at the earliest stages of amyloid deposition and their activation coincides with the clinical expression of Alzheimer’s dementia. This review will examine the origins of complement in the brain and the role of β-amyloid peptide (Aβ) in complement activation in Alzheimer’s disease, an event that might serve as a nidus of chronic inflammation. Pharmacology therapies that may serve to inhibit Aβ-mediated complement activation will also be discussed. |
| Databáze: | OpenAIRE |
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