Medial Temporal Lobe Width on CT Scanning in Alzheimer’s Disease: Comparison with Vascular Dementia, Depression and Dementia with Lewy Bodies
| Autor: | Alan C. Swann, S Metcalfe, J Hobson, John T. O'Brien, Ian G. McKeith, Anil Gholkar, K Jobst, Clive Ballard |
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| Rok vydání: | 2000 |
| Předmět: |
Lewy Body Disease
Male medicine.medical_specialty Pathology Cognitive Neuroscience Temporal lobe Central nervous system disease Degenerative disease Alzheimer Disease Internal medicine mental disorders medicine Humans Dementia Vascular dementia Depression (differential diagnoses) Aged Aged 80 and over Depressive Disorder Dementia with Lewy bodies Dementia Vascular medicine.disease Temporal Lobe Psychiatry and Mental health Cardiology Female Geriatrics and Gerontology Alzheimer's disease Tomography X-Ray Computed Psychology |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000017223 |
| Popis: | A simple linear measurement of the minimum width of the medial temporal lobe (MTL) on angled CT scans has been suggested as an accurate ante-mortem marker for Alzheimer’s disease (AD). To determine the clinical utility and specificity of this finding, we performed angled CT scans with 5-mm slices in 116 subjects referred to a geographically based Old Age Psychiatry service in Newcastle. Diagnoses were of NINCDS/ADRDA AD (n = 69, 36 probable and 33 possible). NINDS/AIREN vascular dementia (VaD, n = 25), consensus criteria for dementia with Lewy bodies (DLB, n = 9) and DSM-IV criteria for major depression (n = 13). Subjects were well matched for age. Minimum MTL width was significantly greater in depressed subjects (13.7 mm) compared to those with dementia, though no differences were seen within the dementia groups (AD 10.8, VaD 10.4, and DLB 10.9 mm). An MTL width below 11.5 mm had a sensitivity of 54% (56/103) and a specificity of 77% (10/13) for distinguishing dementia from depression. We conclude that a single cross-sectional measurement of MTL width on CT does not help differentiate between different types of dementia, though it may provide some supportive evidence when distinguishing depression from dementia. |
| Databáze: | OpenAIRE |
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