Serum ALT Levels as a Surrogate Marker for Serum HBV DNA Levels in HBeAg-negative Pregnant Women
| Autor: | Björn Fischler, Ola Weiland, Madeleine von Sydow, Olle Reichard, Per Sangfelt, Gudrun Lindh, S Lindgren, Ingrid Uhnoo |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Microbiology (medical) Hepatitis B virus HBsAg Molecular Sequence Data Polymerase Chain Reaction Sensitivity and Specificity Statistics Nonparametric Serology Antigen Pregnancy Reference Values Confidence Intervals medicine Humans Mass Screening Serologic Tests Hepatitis B e Antigens Pregnancy Complications Infectious Mass screening Probability Retrospective Studies Sweden Hepatitis Base Sequence General Immunology and Microbiology Surrogate endpoint business.industry Infant Newborn Pregnancy Outcome virus diseases Alanine Transaminase Prenatal Care General Medicine Hepatitis B medicine.disease Infectious Disease Transmission Vertical digestive system diseases Vaccination Infectious Diseases HBeAg Case-Control Studies Carrier State DNA Viral Immunology Female business Biomarkers |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 36:182-185 |
| ISSN: | 1651-1980 0036-5548 |
| DOI: | 10.1080/00365540410027111 |
| Popis: | In Stockholm, Sweden, the majority of pregnant women positive for hepatitis B surface antigen (HBsAg) are hepatitis Be antigen (HBeAg) negative. Newborns to HBeAg positive mothers receive vaccination and hepatitis B immunoglobulin (HBIg). Newborns to HBeAg negative mothers receive vaccine and HBIg only if the mothers have elevated ALT levels. The aim of this study was to retrospectively evaluate ALT levels as a surrogate marker for HBV DNA levels in HBeAg negative carrier mothers. Altogether 8947 pregnant women were screened for HBV markers from 1999 to 2001 at the Virology Department, Karolinska Hospital. Among mothers screened 192 tested positive for HBsAg (2.2%). 13 of these samples could not be retrieved. Of the remaining 179 sera, 8 (4%) tested positive for HBeAg and 171 (95.5%) were HBeAg negative. Among the HBeAg negative mothers, 9 had HBV DNA levels > 10(5) copies/ml, and of these 7 had normal ALT levels indicating low sensitivity of an elevated ALT level as a surrogate marker for high HBV DNA level. Furthermore, no correlation was found between ALT and HBV DNA levels. Hence, it is concluded that the use of ALT as a surrogate marker for high viral replication in HBeAg negative mothers could be questioned. |
| Databáze: | OpenAIRE |
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