Cytotoxic T-lymphocyte and NK responses in mice treated prenatally with chlordane
| Autor: | Jay Gandy, John B. Barnett, Richard Denton, Benny L. Blaylock, Lee S. F. Soderberg, Jay H. Menna |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Cellular immunity Offspring Cell Survival Chlordane Biology Toxicology Natural killer cell chemistry.chemical_compound Mice Sex Factors Orthomyxoviridae Infections Pregnancy Internal medicine medicine Cytotoxic T cell Animals Immunity Cellular Dose-Response Relationship Drug Age Factors General Medicine Killer Cells Natural CTL medicine.anatomical_structure Endocrinology chemistry In utero Chlordan Prenatal Exposure Delayed Effects Toxicity Female T-Lymphocytes Cytotoxic |
| Zdroj: | Toxicology letters. 51(1) |
| ISSN: | 0378-4274 |
| Popis: | It has been reported previously that BALB/c mice, treated in utero with chlordane, showed increased survival to influenza A/PR/8/34 [H1N1] (influenza) virus as young adults [1]. To determine the possible role of cell-mediated immunity (CMI) on this effect, cytotoxic T-lymphocyte (CTL) and natural killer (NK) cell activities were assessed on chlordane-exposed offspring at 100 and 200 days post partum. The CTL response of these offspring showed no significant change from that obtained from their sex- and age matched control counterparts exposed prenatally to the vehicle. NK responses of chlordane-exposed female offspring were significantly higher at 100 days of age but not at 200 days of age. Although male offspring that were exposed to chlordane prenatally showed no difference in NK cell activity at 100 days of age, NK cell activity was significantly less in chlordane-treated animals than controls at 200 days of age. Thus, prenatal treatment of mice with chlordane had varying effects on the NK cell activity of adult offspring, depending on the sex and age of the animal. It is concluded that the previously reported increase in survival to influenza [1] is due to a resolution of the infection by normal CTL and NK cell activities coupled with a decrease in delayed-type hypersensitivity (DTH)-mediated pathology. |
| Databáze: | OpenAIRE |
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