Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L

2)-beta-D-apiofuranoside, and the flavone celtidifoline (5,6,4',5'-tetrahydroxy-7,3'-dimethoxyflavone), along with other 11 known compounds, were isolated from leaves of the ethyl acetate extract of Lantana trifolia L. using step gradient High Speed Countercurrent Chromatography (HSCCC) and High Performance Liquid Chromatography (HPLC), respectively. Their structures were elucidated by spectroscopic methods, including 2D NMR and mass spectrometry (ESI-MS) techniques. The ethanolic and ethyl acetate extracts produced an intense sedative effect in mice, one hour after oral administration of 1 mg/kg. This effect was neither due to a benzodiazepine-like effect of the three flavone derivatives neither of the phenylpropanoids, betonyoside F and verbascoside, that were tested for their affinity for the [3H] flunitrazepam binding sites. -->

ISSN:	1873-3700
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a68495cff48308554f2b63800a2b13 https://pubmed.ncbi.nlm.nih.gov/19922967
Rights:	CLOSED
Přírůstkové číslo:	edsair.doi.dedup.....48a68495cff48308554f2b63800a2b13
Autor:	Patricia Dias Fernandes, Suzana G. Leitão, Gilda Guimarães Leitão, Jean Pierre Barros Thibaut, Anna Lisa Picinelli, François Noël, Cinzia Lotti, Luca Rastrelli, Lisieux de Santana Julião
Rok vydání:	2008
Předmět:	Male Propanols Lantana Ethyl acetate Plant Science Horticulture Mass spectrometry Biochemistry Flavones High-performance liquid chromatography chemistry.chemical_compound Mice Countercurrent chromatography Verbascoside Oral administration Organic chemistry Animals Hypnotics and Sedatives Molecular Biology chemistry.chemical_classification Chromatography Molecular Structure Plant Extracts General Medicine Plant Leaves chemistry Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Phytochemistry. 71(2-3)
ISSN:	1873-3700
Popis:	The flavone glycosides, named scutellarein-7-O-beta-D-apiofuranoside and apigenin-7-O-beta-D-apiofuranosyl-(1-->2)-beta-D-apiofuranoside, and the flavone celtidifoline (5,6,4',5'-tetrahydroxy-7,3'-dimethoxyflavone), along with other 11 known compounds, were isolated from leaves of the ethyl acetate extract of Lantana trifolia L. using step gradient High Speed Countercurrent Chromatography (HSCCC) and High Performance Liquid Chromatography (HPLC), respectively. Their structures were elucidated by spectroscopic methods, including 2D NMR and mass spectrometry (ESI-MS) techniques. The ethanolic and ethyl acetate extracts produced an intense sedative effect in mice, one hour after oral administration of 1 mg/kg. This effect was neither due to a benzodiazepine-like effect of the three flavone derivatives neither of the phenylpropanoids, betonyoside F and verbascoside, that were tested for their affinity for the [3H] flunitrazepam binding sites.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a68495cff48308554f2b63800a2b13 https://pubmed.ncbi.nlm.nih.gov/19922967 Zobrazit plný text záznamu Full Text from ScienceDirect