Surface membrane-associated regulation of cell assembly, differentiation, and growth
| Autor: | N Dainiak |
|---|---|
| Rok vydání: | 1991 |
| Předmět: | |
| Zdroj: | Blood. 78:264-276 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v78.2.264.264 |
| Popis: | The role of the surface membrane in regulating proliferation and differentiation of eukaryotic cells is highly complex. Proximal cell- cell interactions are involved, including physical contact via junctional complexes, exfoliation of surface membrane vesicles, proteolytic cleavage of membrane-bound precursors, and exocytosis of soluble proteins (see Fig 5). At another level, the surface expresses receptors and other proteins that mediate cell-cell adhesion, a multistep event that may be sufficient to activate some growth- associated genes and alter cell shape. The evidence indicates that together with secreted growth factors, surface membrane-associated molecules play a dynamic role in regulating multicellular assembly and cell differentiation and growth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|