Impact of Surface-Active Guanidinium-, Tetramethylguanidinium-, and Cholinium-Based Ionic Liquids on Vibrio Fischeri Cells and Dipalmitoylphosphatidylcholine Liposomes
| Autor: | Alistair W. T. King, Lasse Kyllönen, Antti H. Rantamäki, Susanne K. Wiedmer, Evangelos Sklavounos, Suvi-Katriina Ruokonen |
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| Přispěvatelé: | Department of Chemistry, Susanne Wiedmer / Principal Investigator, HUS Head and Neck Center |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Choline/chemistry
Chemical/chemistry 116 Chemical sciences 0211 other engineering and technologies Ionic Liquids 02 engineering and technology 010501 environmental sciences Ecotoxicology 01 natural sciences Micelle Choline chemistry.chemical_compound Water Pollutants IMIDAZOLIUM 2-Dipalmitoylphosphatidylcholine/chemistry chemistry.chemical_classification Liposome Multidisciplinary Calorimetry Differential Scanning Phase Transition/drug effects AQUATIC ORGANISMS Aliivibrio fischeri/drug effects Aliivibrio fischeri Membrane Toxicity BIODEGRADABILITY 1 2-Dipalmitoylphosphatidylcholine/chemistry Liposomes/chemistry BEHAVIOR 1 2-Dipalmitoylphosphatidylcholine Inorganic chemistry TOXICITY ASSESSMENT Calorimetry Differential Scanning Phase Transition Article MARINE-BACTERIA Microbiology Differential scanning calorimetry Seawater/microbiology Seawater SDG 14 - Life Below Water Alkyl Guanidine 0105 earth and related environmental sciences 021110 strategic defence & security studies VIABILITY Water Pollutants Chemical/chemistry Ecotoxicology/methods ECOTOXICITY Guanidine/chemistry chemistry 13. Climate action Dipalmitoylphosphatidylcholine Ionic liquid Liposomes CHAIN Ionic Liquids/chemistry Water Pollutants Chemical |
| Zdroj: | Scientific Reports Rantamäki, A H, Ruokonen, S K, Sklavounos, E, Kyllönen, L, King, A W T & Wiedmer, S K 2017, ' Impact of surface-active guanidinium-, tetramethylguanidinium-, and cholinium-based ionic liquids on vibrio Fischeri cells and dipalmitoylphosphatidylcholine liposomes ', Scientific Reports, vol. 7, 46673 . https://doi.org/10.1038/srep46673 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep46673 |
| Popis: | We investigated the toxicological effect of seven novel cholinium, guanidinium, and tetramethylguanidinium carboxylate ionic liquids (ILs) from an ecotoxicological point of view. The emphasis was on the potential structure-toxicity dependency of these surface-active ILs in aqueous environment. The median effective concentrations (EC50) were defined for each IL using Vibrio (Aliivibrio) fischeri marine bacteria. Dipalmitoylphosphatidylcholine (DPPC) liposomes were used as biomimetic lipid membranes to study the interactions between the surface-active ILs and the liposomes. The interactions were investigated by following the change in the DPPC phase transition behaviour using differential scanning calorimetry (DSC). Critical micelle concentrations for the ILs were determined to clarify the analysis of the toxicity and the interaction results. Increasing anion alkyl chain length increased the toxicity, whereas branching of the chain decreased the toxicity of the ILs. The toxicity of the ILs in this study was mainly determined by the surface-active anions, while cations induced a minor impact on the toxicity. In the DSC experiments the same trend was observed for all the studied anions, whereas the cations seemed to induce more variable impact on the phase transition behaviour. Toxicity measurements combined with liposome interaction studies can provide a valuable tool for assessing the mechanism of toxicity. |
| Databáze: | OpenAIRE |
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