Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine
| Autor: | Alan D.T. Barrett, Miguel T. Suderman, Thomas P. Monath, Li Li, Robert E. Shope, Farshad Guirakhoo, Dennis W. Trent, David W.C. Beasley |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Genotype
Recombinant Fusion Proteins viruses Antibodies Viral Neutralization Virus Microbiology Mice Flaviviridae Neutralization Tests medicine Animals Encephalitis Japanese Encephalitis Virus Japanese Antiserum Mice Inbred ICR General Veterinary General Immunology and Microbiology biology Japanese Encephalitis Vaccines Immunization Passive Public Health Environmental and Occupational Health Japanese encephalitis medicine.disease biology.organism_classification Survival Analysis Virology Mice Inbred C57BL Flavivirus Infectious Diseases Immunization Molecular Medicine Encephalitis |
| Zdroj: | Vaccine. 22:3722-3726 |
| ISSN: | 0264-410X |
| Popis: | The ability of antisera raised against a candidate Japanese encephalitis virus (JEV) vaccine, ChimeriVax™-JE, and the currently licensed vaccine, JE-VAX®, to protect against strains of JEV representing the four major genotypes was assessed. Neutralization assays and passive protection studies in mice showed that greatest protection was provided against strains of genotypes II and III, although some protection was also afforded against genotypes I and IV strains. ChimeriVax™-JE stimulated protection that was comparable or superior to the JE-VAX® control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect