Group A streptococcal antigen in the glomeruli of children with henoch-schönlein nephritis
| Autor: | Norishige Yoshikawa, Koichi Nakanishi, Nobuyuki Yoshizawa, Miwa Masuda, Kazumoto Iijima |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Henoch-Schonlein purpura Adolescent IgA Vasculitis Streptococcus pyogenes Kidney Glomerulus Antistreptolysin Pathogenesis Glomerulonephritis Antigen Streptococcal Infections Humans Medicine Child Antigens Bacterial business.industry Glomerular mesangium medicine.disease Antibodies Bacterial Immune complex Glomerular Mesangium Nephrology Mesangium Child Preschool Immunology Female business Nephritis Fluorescein-5-isothiocyanate |
| Zdroj: | American Journal of Kidney Diseases. 41:366-370 |
| ISSN: | 0272-6386 |
| Popis: | Although the pathogenesis of Henoch-Schönlein nephritis (HSN) remains unclear, there is substantial evidence that it is an immune complex-mediated disease. HSN is preceded by upper-respiratory tract infection in 30% to 50% of patients, but there is no evidence that group A streptococcal (GAS) infection has a pathogenetic role in this disease. Recently, nephritis-associated plasmin receptor (NAPlr), a GAS antigen, was found primarily in the glomerular mesangium of patients with early-stage acute poststreptococcal glomerulonephritis.To determine the possible role of NAPlr in HSN, expression of the receptor was determined in glomeruli using fluorescein isothiocyanate-labeled rabbit polyclonal anti-NAPIr antibody, and serum antistreptolysin O (ASO) titers were measured in children with HSN.Ten of 33 patients (30%) with HSN showed segmental or global mesangial staining with NAPlr antibody, whereas only 4 of 120 patients (3%) with other renal diseases were positive (P0.001, Fisher's exact test). Patients with HSN also showed significantly greater ASO titers than patients with other renal diseases (P = 0.03, Mann-Whitney U test). Serum ASO titers were significantly greater in patients with HSN with than without glomerular NAPlr antigen (P = 0.03, Mann-Whitney U test).These findings suggest that the deposition of NAPlr in the mesangium, induced by GAS infection, may have a role in the pathogenesis of HSN in some patients. Am J Kidney Dis 41:366-370. |
| Databáze: | OpenAIRE |
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