Models of Inflammation: Carrageenan- or Complete Freund's Adjuvant (CFA)-Induced Edema and Hypersensitivity in the Rat
| Autor: | Kenneth E. McCarson, Jill C. Fehrenbacher |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Analgesic Freund's Adjuvant Health Informatics Inflammation Sensory system Pharmacology Carrageenan General Biochemistry Genetics and Molecular Biology Trigeminal ganglion chemistry.chemical_compound Edema medicine Hypersensitivity Animals General Pharmacology Toxicology and Pharmaceutics General Immunology and Microbiology business.industry General Neuroscience Rats Medical Laboratory Technology Nociception chemistry medicine.symptom business Adjuvant |
| Zdroj: | Current protocolsLiterature CitedKey References. 1(7) |
| ISSN: | 2691-1299 |
| Popis: | Animal models of inflammation are used to assess the production of inflammatory mediators at sites of inflammation, the processing of pain sensation at CNS sites, the anti-inflammatory properties of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), and the efficacy of putative analgesic compounds in reversing cutaneous hypersensitivity. Detailed in this article are methods to elicit and measure carrageenan- and complete Freund's adjuvant (CFA)-induced cutaneous inflammation. Due to possible differences between the dorsal root sensory system and the trigeminal sensory system, injections into either the footpad or vibrissal pad are described. In this manner, cutaneous inflammation can be assessed in tissue innervated by the lumbar dorsal root ganglion neurons (footpad) or by the trigeminal ganglion neurons (vibrissal pad). © 2021 Wiley Periodicals LLC. |
| Databáze: | OpenAIRE |
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