Is praziquantel preventive chemotherapy associated with visual disorders in Eritrea? A comment on the case series reported by Debesai and Russom

Autor: Pauline Mwinzi, Amadou Garba, Anthony W. Solomon, Jonathan D. King, Antonio Montresor
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Pediatrics
Databases
Factual
medicine.medical_treatment
Neurocysticercosis
RC955-962
Helminthiasis
Global Health
Praziquantel
Geographical Locations
Pharmacovigilance
Medical Conditions
Risk Factors
Arctic medicine. Tropical medicine
Global health
Medicine and Health Sciences
Schistosomiasis
Public and Occupational Health
Child
Visual Impairments
Anthelmintics
Pharmaceutics
Middle Aged
Infectious Diseases
Research Design
Helminth Infections
Female
Public aspects of medicine
RA1-1270
medicine.drug
Neglected Tropical Diseases
Adult
medicine.medical_specialty
Drug Administration
Adolescent
Clinical Research Design
MEDLINE
Vision Disorders
Eritrea
Research and Analysis Methods
Formal Comment
Young Adult
Drug Therapy
medicine
Parasitic Diseases
Chemotherapy
Adverse Drug Reaction Reporting Systems
Humans
Adverse effect
Aged
business.industry
Public Health
Environmental and Occupational Health
medicine.disease
Tropical Diseases
Visual Disorders
Ophthalmology
People and Places
Africa
Adverse Events
business
Zdroj: PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008827 (2020)
PLoS Neglected Tropical Diseases
ISSN: 1935-2735
1935-2727
Popis: Praziquantel has been in use by helminthiasis and schistosomiasis control programs for about 30 years. Although deemed to be safe with regard to its adverse drug reaction profile in reference to the product information of Biltricide, the Eritrean Pharmacovigilance Center received reports of visual abnormalities related to the drug. This is a case series assessment of unusual cases of visual abnormalities associated with praziquantel.Search was made in VigiBase by setting praziquantel as a drug substance, Eritrea as the reporting country and all eye disorders, high level term (HLT) to capture all visual disorders associated with Praziquantel. The retrieved dataset was exported into an Excel spreadsheet for descriptive analysis and causality was assessed using Austin Bradford-Hill criteria.There are a total of 2579 Individual Case Safety Reports (ICSRs) of various Adverse Drug Reactions (ADRs) of praziquantel reported from Eritrea in VigiBase. The 61 reports of visual abnormalities that arose within the first 24 hours of praziquantel administration are of note. With a strong association as evidenced by the positive IC025 value, the association of praziquantel and blurred vision was consistently reported from different health facilities over a period of three years. It is a specific association in terms of both the exposure (only praziquantel) and the outcome (blurred vision) as reported in majority of the cases. However, experimental evidences for the association are lacking, the underweight profile of the Eritrean population suggests overdosing as a possible risk factor for the occurrence of these reactions.The strength, temporal plausibility, consistency and specificity of the association are suggestive of a causal association between praziquantel and visual disorders.
Databáze: OpenAIRE
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