Appetite suppression based on selective inhibition of NPY receptors
| Autor: | Michel Félétou, Nigel Levens, J.-P Galizzi, O. Della-Zuana, Susana Chamorro, Jean-Luc Fauchère |
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| Rok vydání: | 2002 |
| Předmět: |
Drug
medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject Medicine (miscellaneous) Endogeny Naphthalenes Biology Antibodies Oligodeoxyribonucleotides Antisense Eating Mice Internal medicine Appetite Depressants mental disorders medicine Animals Humans Neuropeptide Y Receptor media_common Mice Knockout Nutrition and Dietetics Drug discovery Antagonist Brain Appetite Neuropeptide Y receptor humanities Receptors Neuropeptide Y Blockade Pyrimidines Endocrinology Drug Design Energy Metabolism |
| Zdroj: | International Journal of Obesity. 26:281-298 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/sj.ijo.0801948 |
| Popis: | AIM: The aim of this review is to critically assess available evidence that blockade of the actions of NPY at one of the five NPY receptor subtypes represents an attractive new drug discovery target for the development of an appetite suppressant drug. RESULTS: Blockade of the central actions of NPY using anti-NPY antibodies, antisense oligodeoxynucleotides against NPY and NPY receptor antagonists results in a decrease in food intake in energy-deprived animals. These results appear to show that endogenous NPY plays a role in the control of appetite. The fact that NPY receptors exist as at least five different subtypes raises the possibility that the actions of endogenous NPY on food intake can be adequately dissociated from other effects of the peptide. Current drug discovery has produced a number of highly selective NPY receptor antagonists which have been used to establish the NPY Y1 receptor subtype as the most critical in regulating short-term food intake. However, additional studies are now needed to more clearly define the relative contribution of NPY acting through the NPY Y2 and NPY Y5 receptors in the complex sequence of physiological and behavioral events that underlie the long-term control of appetite. CONCLUSIONS: Blockade of the NPY receptor may produce appetite-suppressing drugs. However, it is too early to state with certainty whether a single subtype selective drug used alone or a combination of NPY receptor selective antagonists used in combination will be necessary to adequately influence appetite regulation. |
| Databáze: | OpenAIRE |
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