Preventive Effects of Curcumin on the Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Male C57BL/KsJ-db/dbObese Mice

Autor:	Hisashi Tsurumi, Hisataka Moriwaki, Takuji Tanaka, Atsushi Baba, Yoichi Yasuda, Masahito Shimizu, Tomohiko Ohno, Hiroyasu Sakai, Daishi Terakura, Masaya Kubota
Rok vydání:	2012
Předmět:	Leptin Male Cancer Research medicine.medical_specialty Curcumin Colon Colorectal cancer Azoxymethane Mice Obese Medicine (miscellaneous) Inflammation Mice Basal (phylogenetics) chemistry.chemical_compound AMP-Activated Protein Kinase Kinases Internal medicine medicine Animals Anticarcinogenic Agents Obesity Intestinal Mucosa Nutrition and Dietetics Interleukin-6 Tumor Necrosis Factor-alpha Kinase business.industry NF-kappa B Cancer Organ Size medicine.disease Mice Inbred C57BL Endocrinology Adipose Tissue Oncology chemistry Cyclooxygenase 2 Colonic Neoplasms Dietary Supplements Tumor necrosis factor alpha Adiponectin medicine.symptom business Precancerous Conditions Protein Kinases
Zdroj:	Nutrition and Cancer. 64:72-79
ISSN:	1532-7914 0163-5581
Popis:	Obesity-related metabolic abnormalities include a state of chronic inflammation and adipocytokine imbalance, which increase the risk of colon cancer. Curcumin, a component of turmeric, exerts both cancer preventive and antiinflammatory properties. Curcumin is also expected to have the ability to reverse obesity-related metabolic derangements. The present study examined the effects of curcumin on the development of azoxymethane (AOM)-induced colonic premalignant lesions in C57BL/KsJ-db/db (db/db) obese mice. Feeding with a diet containing 0.2% and 2.0% curcumin caused a significant reduction in the total number of colonic premalignant lesions compared with basal diet-fed mice. The expression levels of tumor necrosis factor-α, interleukin-6, and cyclooxygenase-2 (COX-2) mRNAs on the colonic mucosa of AOM-treated mice were significantly decreased by curcumin administration. Dietary feeding with curcumin markedly activated AMP-activated kinase, decreased the expression of COX-2 protein, and inhibited nuclear factor-κB activity on the colonic mucosa of AOM-treated mice. Curcumin also increased the serum levels of adiponectin while conversely decreasing the serum levels of leptin and the weights of fat. In conclusion, curcumin inhibits the development of colonic premalignant lesions in an obesity-related colorectal carcinogenesis model, at least in part, by attenuating chronic inflammation and improving adipocytokine imbalance. Curcumin may be useful in the chemoprevention of colorectal carcinogenesis in obese individuals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489e621f82387b09ad17b4480075a3b2 https://doi.org/10.1080/01635581.2012.630554 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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