Significant association between systolic and diastolic blood pressure elevations and periodic limb movements in patients with idiopathic restless legs syndrome
| Autor: | Frank Grieger, Karl Kesper, Axel Bauer, Claudia Trenkwalder, Lars Joeres, Werner Cassel, Erwin Schollmayer |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Systole Polysomnography Diastole Blood Pressure Nocturnal Myoclonus Syndrome Young Adult 03 medical and health sciences 0302 clinical medicine Heart Rate Risk Factors Restless Legs Syndrome Internal medicine Heart rate medicine Humans Restless legs syndrome Aged medicine.diagnostic_test business.industry Rotigotine General Medicine Middle Aged medicine.disease 3. Good health Surgery Blood pressure 030228 respiratory system Cardiology Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Sleep Medicine. 17:109-120 |
| ISSN: | 1389-9457 |
| DOI: | 10.1016/j.sleep.2014.12.019 |
| Popis: | Objective A new and unique methodology was developed to evaluate the association between periodic limb movements (PLMs) and nocturnal blood pressure (BP) excursions in patients with restless legs syndrome (RLS). Methods All data were collected at baseline of the ENCORE (Effects of Neupro on Cardiovascular Observations in Patients with Restless Legs Syndrome) study, a placebo-controlled polysomnographic study of rotigotine in patients with idiopathic RLS. Continuous beat-by-beat BP and heart rate assessments were performed during a full night of polysomnography. All BP elevations occurring with and without PLMs were systematically identified and analyzed. Results Patients ( n = 89) had a mean total of 508.9 ± 405.7 PLMs, 788.4 ± 261.9 systolic BP elevations, and 349.7 ± 242.9 diastolic BP elevations during the night. Higher time-adjusted frequencies of systolic BP elevations [mean difference (95% confidence interval, CI): 543.0 (487.2, I); p 0.0001] and diastolic BP elevations (205.8 (169.3, I); p 0.0001) were observed with PLMs than without PLMs. A peak in the frequency of PLM onset coincided with BP elevation onset. Conclusion Our methodology allowed the first evaluation of the total number of nocturnal PLM-associated BP elevations occurring in patients with RLS. Our data clearly indicate an interdependence between BP elevations and PLMs, and they have clinical relevance as BP variability is a potential cardiovascular risk factor. |
| Databáze: | OpenAIRE |
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