Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency
| Autor: | Olga Martinez-Arroyo, Santiago Díaz-Oltra, Francisco Galindo, Carles Felip-León, Nadezda Apostolova, Juan F. Miravet |
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| Přispěvatelé: | Technical support from SCIC of University Jaume I is acknowledged. |
| Rok vydání: | 2017 |
| Předmět: |
Cell type
Cell Survival Ultraviolet Rays medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Photodynamic therapy 010402 general chemistry 01 natural sciences Biochemistry singlet oxygen Umbilical vein chemistry.chemical_compound Structure-Activity Relationship Cell Line Tumor Drug Discovery medicine Human Umbilical Vein Endothelial Cells Bioassay Humans Molecular Biology Cell Proliferation Photosensitizing Agents Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Chemistry Singlet oxygen Organic Chemistry Acridine derivatives Chromophore 0104 chemical sciences 9-Amidoacridine photodynamic therapy Microscopy Fluorescence Photochemotherapy Cell culture organic nanoparticles Biophysics Molecular Medicine Acridines self-aggregation |
| Zdroj: | Repositori Universitat Jaume I Universitat Jaume I |
| ISSN: | 1464-3405 |
| Popis: | Two new photoactive compounds (1 and 2) derived from the 9-amidoacridine chromophore have been synthesized and fully characterized. Their abilities to produce singlet oxygen upon irradiation have been compared. The synthesized compounds show very different self-aggregating properties since only 1 present a strong tendency to aggregate in water. Biological assays were conducted with two cell types: hepatoma cells (Hep3B) and human umbilical vein endothelial cells (HUVEC). Photodynamic therapy (PDT) studies carried out with Hep3B cells showed that non-aggregating compound 2 showed photoxicity, ascribed to the production of singlet oxygen, being aggregating compound 1 photochemically inactive. On the other hand suspensions of 1, characterized as nano-sized aggregates, have notable antiproliferative activity towards this cell line in the dark. |
| Databáze: | OpenAIRE |
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