Thyroid disorders after radiation therapy in childhood
| Autor: | Sergey Semochkin, Mariya Gennadyevna Pavlova, V M Sotnikov, Yuliya Petrovna Sych, Roman Alekseevich Parkhomenko, Ekaterina Ivanovna Bobrova, Nadezhda Mazerkina, Valentin V. Fadeyev, Olga Zheludkova |
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| Rok vydání: | 2014 |
| Předmět: |
Thyroid nodules
medicine.medical_specialty radioinduced cancer business.industry Incidence (epidemiology) medicine.medical_treatment Thyroid Cancer General Medicine RC648-665 medicine.disease Gastroenterology Diseases of the endocrine glands. Clinical endocrinology Craniospinal Irradiation thyroid Radiation therapy medicine.anatomical_structure Internal medicine medicine hypothyroidism Thyroid function Nuclear medicine business Cervix radiotherapy |
| Zdroj: | Клиническая и экспериментальная тиреоидология, Vol 10, Iss 3, Pp 45-52 (2014) |
| ISSN: | 2310-3787 1995-5472 |
| Popis: | Aim The aim of our study was to analyze thyroid status in adults after treatment for malignancies in childhood and its relationship with dose and type of radiotherapy. Material and methods Thyroid function (TSH, free T4, anti-TPO), thyroid ultrasound and FNA (in case of thyroid nodules more than 1 cm) were evaluated in 106 adults with a history of radiotherapy for brain tumors (BT), acute lymphoblastic leukemia (ALL) and Hodgkin's lymphoma (HL) in childhood and compared with that in healthy controls (n = 33). Group 1 (cranial irradiation 18 Gy): 11 men and 17 women (median age 21.7 ± 4.2 yrs (range 15–30)), 14.6 ± 4 years after treatment for ALL. Group 2 (craniospinal irradiation 35 Gy + boost to the tumor 55 Gy): 28 men and 20 women (median age 19.48 ± 2.76 yrs (range 15 – 26), 7.84 ± 4.68 years after treatment for brain tumors (BT). Group 3 (local irradiation of cervix and mediastinum mean dose 30.9 ± 9.17 Gy): 13 men and 16 women (median age 28.2 ± 6.31 yrs (range 17 – 44), 11.37 ± 7.25 years after treatment for HL. Results Maximal incidence of hypothyroidism was in the group 2 – 58.3% (35.4% – primary, 4.2% – central, 18.8% – mixed). Prevalence of hypothyroidism in groups 1 (9.09%) and 3 (17.24%) doesn't significantly differ from controls. Thyroid volume was lower (mean 4.58±2.39 ml) in group 2 (p |
| Databáze: | OpenAIRE |
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