Bipolar Disorder Among Patients Diagnosed With Frontotemporal Dementia
| Autor: | Mario F. Mendez, Golnoush Akhlaghipour, Leila Parand |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Prodromal Symptoms behavioral disciplines and activities Article 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Bipolar disorder Age of Onset Psychiatry Aged Retrospective Studies business.industry Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Mania Psychiatry and Mental health Frontotemporal Dementia Positron-Emission Tomography Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | J Neuropsychiatry Clin Neurosci |
| ISSN: | 1545-7222 0895-0172 |
| DOI: | 10.1176/appi.neuropsych.20010003 |
| Popis: | Previous studies have documented manic and hypomanic symptoms in behavioral variant frontotemporal dementia (bvFTD), suggesting a relationship between bipolar disorder and bvFTD.The investigators conducted a literature review as well as a review of the psychiatric histories of 137 patients with bvFTD, and patients with a prior diagnosis of bipolar disorder were identified. The clinical characteristics of patients' bipolar disorder diagnosis, family history, features of bvFTD, and results from fluorodeoxyglucose positron emission tomography (FDG-PET), as well as autopsy findings, were evaluated.Among the 137 patients, 14 (10.2%) had a psychiatric diagnosis of bipolar disorder, eight of whom met criteria for bipolar disorder (type I, N=6; type II, N=2) 6-12 years preceding onset of classic symptoms of progressive bvFTD. Seven of the eight patients with bipolar disorder had a family history of mood disorders, four had bitemporal predominant hypometabolism on FDG-PET, and two had a tauopathy involving temporal lobes on autopsy. Three additional patients with late-onset bipolar I disorder proved to have a nonprogressive disorder mimicking bvFTD. The remaining three patients with bvFTD had prior psychiatric symptoms that did not meet criteria for a diagnosis of bipolar disorder. The literature review and the findings for one patient further suggested a shared genetic mutation in some patients.Manic or hypomanic episodes years before other symptoms of bvFTD may be a prodrome of this dementia, possibly indicating anterior temporal involvement in bvFTD. Other patients with late-onset bipolar disorder exhibit the nonprogressive frontotemporal dementia phenocopy syndrome. Finally, a few patients with bvFTD have a genetic predisposition for both disorders. |
| Databáze: | OpenAIRE |
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