Acute tolerance associated with a single opiate administration: involvement of N-methyl-d-aspartate-dependent pain facilitatory systems
| Autor: | Agnès Larcher, Jean-Paul Laulin, M. Le Moal, E. Célérier, Guy Simonnet |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.drug_class Analgesic Pain (+)-Naloxone Pharmacology Heroin Rats Sprague-Dawley Reaction Time medicine Animals Pain Measurement Analysis of Variance Naloxone business.industry General Neuroscience Glutamate receptor Drug Tolerance Receptor antagonist Rats Analgesics Opioid Hyperalgesia NMDA receptor Dizocilpine Maleate medicine.symptom Opiate business medicine.drug |
| Zdroj: | Neuroscience. 84:583-589 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/s0306-4522(97)00556-3 |
| Popis: | Mechanisms underlying the development of acute tolerance to the analgesic effect of opiates were investigated. In the rat tail-flick test, administration of naloxone (1 mg/kg, s.c.) 40 min after heroin (1 mg/kg, s.c.) was shown to induce hyperalgesia, indicative of a short-onset, opiate-activated pain facilitatory systems masking the opiate analgesia. Pretreatment with the N-methyl-D-aspartate receptor antagonist dizocilpine maleate blocked, in a dose-dependent manner, the naloxone-induced hyperalgesia and potentiated the heroin-induced analgesia. Using a schedule of two successive injections of 1 mg/kg heroin, acute tolerance was indicated by a marked reduction (-52%) in analgesia induced by the second dose. After pretreatment with dizocilpine maleate, the acute tolerance was abolished and the analgesic effects of both injections of heroin were strongly potentiated. These observations indicate that acute tolerance appears after the first exposure to opiates and stems from opiate activation of N-methyl-D-aspartate-dependent pain facilitatory systems. |
| Databáze: | OpenAIRE |
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