Steroid pulse therapy impaired endothelial function while increasing plasma high molecule adiponectin concentration in patients with IgA nephropathy
| Autor: | Hirofumi Makino, Yoshio Nakamura, Hisanao Norii, Masanobu Kaihara, Yohei Maeshima, Yoshihisa Hanayama, Hitoshi Sugiyama, Yasushi Yamasaki, Haruhito A. Uchida |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Vasodilation Methylprednisolone Nephropathy chemistry.chemical_compound Internal medicine medicine Humans Endothelial dysfunction Glucocorticoids Transplantation Adiponectin business.industry Glomerulonephritis IGA medicine.disease Endocrinology chemistry Nephrology Pulse Therapy Drug Hepatocyte growth factor Female Endothelium Vascular Asymmetric dimethylarginine business Glucocorticoid medicine.drug Kidney disease |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 21(12) |
| ISSN: | 0931-0509 |
| Popis: | BACKGROUND Decreased plasma adiponectin is associated with impaired endothelial function and, thereby, increased risk for cardiovascular events. Glucocorticoid (GC) affects vascular endothelial cells either favourably or harmfully depending upon the dosages and duration. We examined the effect of GC pulse therapy on vascular endothelial function. METHODS Fourteen young patients with IgA nephropathy were evaluated for flow-mediated vasodilation (FMD), plasma levels of adiponectin both in high molecular weight (HMW adiponectin) form and in single molecular form (total adiponectin), hepatocyte growth factor (HGF), asymmetric dimethylarginine (ADMA), and high-sensitive C-reactive protein, before and after a course of GC pulse therapy. RESULTS GC pulse therapy significantly decreased FMD (from 7.2 +/- 2.6 to 5.7 +/- 2.5%, P < 0.01). Meanwhile, plasma adiponectin levels were significantly augmented (total adiponectin: from 10.2 +/- 4.0 to 12.1 +/- 6.3 microg/ml, P < 0.05; HMW: from 6.5 +/- 3.2 to 7.7 +/- 3.3 microg/ml, P < 0.05). In parallel, elevated concentrations of serum HGF (from 0.28 +/- 0.12 to 0.63 +/- 0.38 ng/ml, P < 0.01) and plasma ADMA (from 0.45 +/- 0.07 to 0.53 +/- 0.04 nmol/ml, P < 0.05) were observed. CONCLUSIONS GC pulse therapy impaired endothelial function while increasing plasma adiponectin levels, which may in turn restore the endothelial function in patients with IgA nephropathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|